ArticleACS photonics2018
Quantifying the Limits of Detection of Surface-Enhanced Infrared Spectroscopy with Grating Order-Coupled Nanogap Antennas.
Article in ACS photonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rigid tetrahedral DNA nanostructures on graphene-assisted plasmonic sensor for highly sensitive infrared fingerprinting.Analytical and bioanalytical chemistry · 2026Article
- Polarization-independent dielectric gradient near-perfect absorbers for aqueous mid-infrared molecular sensing.Npj nanophotonics · 2026Article
- Mass-Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid-IR Spectrochemical Analysis of Complex Biofluids.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Physics-informed deep learning for plasmonic sensing of nanoscale protein dynamics in solution.Science advances · 2025Article
- High-Precision Biochemical Sensing with Resonant Monocrystalline Plasmonic Ag Microcubes in the Mid-Infrared Spectrum.ACS nano · 2025Article
- Protocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy.Analytical chemistry · 2024Article
- Design and Development of Metasurface Materials for Enhancing Photodetector Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Grating Structures for Silver-Based Surface Plasmon Resonance Sensors with Adjustable Excitation Angle.Sensors (Basel, Switzerland) · 2024Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- Over-coupled resonator for broadband surface enhanced infrared absorption (SEIRA).Nature communications · 2023Article
- Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases.Science advances · 2023Article
- Plasmonic bound states in the continuum to tailor light-matter coupling.Science advances · 2022Article
- On the Limit of Detection in Infrared Spectroscopic Imaging.Applied spectroscopy · 2022Article
- Multifunctional Chemical Sensing Platform Based on Dual-Resonant Infrared Plasmonic Perfect Absorber for On-Chip Detection of Poly(ethyl cyanoacrylate).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Wafer-Scale Functional Metasurfaces for Mid-Infrared Photonics and Biosensing.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Engineered nano-sphere array of gold-DNA core-shells and junctions as opto-plasmonic sensors for biodetection.RSC advances · 2021Article
- Infrared Metasurface Augmented by Deep Learning for Monitoring Dynamics between All Major Classes of Biomolecules.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Graphene based hyperbolic metamaterial for tunable mid-infrared biosensing.RSC advances · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infrared spectroscopy is widely used for biomolecular studies, but struggles when investigating minute quantities of analytes due to the mismatch between vibrational cross sections and IR wavelengths. It is therefore beneficial to enhance absorption signals by confining the infrared light to deeply subwavelength volumes comparable in size to the biomolecules of interest. This can be achieved with surface-enhanced infrared absorption spectroscopy, for which plasmonic nanorod antennas represent the predominant implementation. However, unifying design guidelines for such systems are still lacking. Here, we introduce an experimentally verified framework for designing antenna-based molecular IR spectroscopy sensors. Specifically, we find that in order to maximize the sensing performance, it is essential to combine the signal enhancement originating from nanoscale gaps between the antenna elements with the enhancement obtained from coupling to the grating order modes of the unit cell. Using an optimized grating order-coupled nanogap design, our experiments and numerical simulations show a hotspot limit of detection of two proteins per nanogap. Furthermore, we introduce and analyze additional limit of detection parameters, specifically for deposited surface mass, in-solution concentration, and secondary structure determination. These limits of detection provide valuable reference points for performance metrics of surface-enhanced infrared absorption spectroscopy in practical applications, such as the characterization of biological samples in aqueous solution.
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Registered trials
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