ArticleJournal of intensive care2019
Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort.
Article in Journal of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2022Pooled it
- Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients.Infection · 2026Article
- Sequential Application of Time-Stratified Demographic, Vital, Clinical-Laboratory, and Microbiology Variables for Accurate and Rapid Identification of Sepsis.Diseases (Basel, Switzerland) · 2026Article
- Risk factors associated with apyrexia during bacteraemia: a prospective multicenter cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Early Identification of a Cytokine-Low Immune Phenotype in Suspected Sepsis Using a Point-of-Care Whole-Blood TNF-α Release Assay.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Point-of-care LPS-induced TNF-α release testing for early sepsis risk stratification in the emergency department.Frontiers in immunology · 2026Observational
- Adjudication instrument for infection in critically injured trauma patients.Trauma surgery & acute care open · 2026Article
- Ventilator-Associated Pneumonia (VAP) in Neurocritical Patients: The Hidden Dialog of Brain and Infection.Biomedicines · 2025Review
- Temporal validation of the Ramathibodi Older Sepsis Score (ROSS) for predicting 28-day mortality of older sepsis patients in the emergency department.BMC emergency medicine · 2025Article
- Impact of a Sepsis Quality Improvement Initiative on Clinical and Operational Outcomes.Healthcare (Basel, Switzerland) · 2025Article
- Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: a retrospective study.Scientific reports · 2025Article
- "Sepsis brought him to his knees": exploring the lived experiences and perspectives of sepsis survivors and family members to inform a sepsis public education campaign in Canada.BMC public health · 2025Article
- Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.Journal of clinical medicine · 2024Article
- Improving Sepsis Outcomes in the Era of Pay-for-Performance and Electronic Quality Measures: A Joint IDSA/ACEP/PIDS/SHEA/SHM/SIDP Position Paper.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation.Journal of clinical medicine · 2024Article
- Development of a Clinical Score for Predicting 28-Day Mortality in Geriatric Sepsis Patients; a Cohort study.Archives of academic emergency medicine · 2024Article
- The Accuracy of Infection Diagnoses Among Patients Meeting Sepsis-3 Criteria in the Emergency Department.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Reply to Adelman et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Prevalence, Clinical Characteristics, and Outcomes of Sepsis Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Versus Other Pathogens in Hospitalized Patients With COVID-19.Critical care explorations · 2022Article
Corrections and comments
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Authors and funding
29 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundDifferentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and variable training and experience of attending physicians. Our objective was to describe and quantify physician agreement in diagnosing SIRS or sepsis in critical care patients as a function of available clinical information, infection site, and hospital setting.
methodsWe conducted a post hoc analysis of previously collected data from a prospective, observational trial (
resultsFree-marginal kappa decreased between the initial impression of the attending physician and (1) the initial impression of the site investigator (
conclusionsConsiderable uncertainty surrounds the differential clinical diagnosis of sepsis vs. SIRS, especially before organ damage has become highly evident, and for patients presenting with respiratory clinical signs. Our findings underscore the need to provide physicians with accurate, timely diagnostic information in evaluating possible sepsis.
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Registered trials
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