Evidence map›Paper›PMID 30828449›Full record

ArticleJournal of nutritional science2019

Association between vegetarian diets and cardiovascular risk factors in non-Hispanic white participants of the Adventist Health Study-2.

Seiji Matsumoto, W Lawrence Beeson, David J Shavlik, Gina Siapco, Karen Jaceldo-Siegl, Gary Fraser, Synnove F Knutsen

Open access · goldAbstract read
In one paragraph

Article in Journal of nutritional science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Vegetarian Dietary Patterns and Diet-Related Metabolites Are Associated With Kidney Function in the Adventist Health Study-2 Cohort.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Seiji MatsumotoCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
W Lawrence BeesonCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
David J ShavlikCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Gina SiapcoCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Karen Jaceldo-SieglCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Gary FraserAdventist Health Study-2, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Synnove F KnutsenCenter for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA 92354, USA.
Loma Linda University · US

Funding

CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUPR01CA094594 · NCI · LOMA LINDA UNIVERSITY · PI FRASER, GARY E. · 2001 to 2008
$18.0M
Plant-based diets and risk of cancerU01CA152939 · NCI · LOMA LINDA UNIVERSITY · PI FRASER, GARY E. · 2011 to 2015
$5.7M
NCI NIH HHS R01 CA094594NCI NIH HHS U01 CA152939
6 · The paper itself

Abstract

The association between dietary patterns and CVD risk factors among non-Hispanic whites has not been fully studied. Data from 650 non-Hispanic white adults who participated in one of two clinical sub-studies (about 2 years after the baseline) of the Adventist Health Study-2 (AHS-2) were analysed. Four dietary patters were identified using a validated 204-item semi-quantitative FFQ completed at enrolment into AHS-2: vegans (8·3 %), lacto-ovo-vegetarians (44·3 %), pesco-vegetarians (10·6 %) and non-vegetarians (NV) (37·3 %). Dietary pattern-specific prevalence ratios (PR) of CVD risk factors were assessed adjusting for confounders with or without BMI as an additional covariable. The adjusted PR for hypertension, high total cholesterol and high LDL-cholesterol were lower in all three vegetarian groups. Among the lacto-ovo-vegetarians the PR were 0·57 (95 % CI 0·45, 0·73), 0·72 (95 % CI 0·59, 0·88) and 0·72 (95 % CI 0·58, 0·89), respectively, which remained significant after additionally adjusting for BMI. The vegans and the pesco-vegetarians had similar PR for hypertension at 0·46 (95 % CI 0·25, 0·83) and 0·62 (95 % CI 0·42, 0·91), respectively, but estimates were attenuated and marginally significant after adjustment for BMI. Compared with NV, the PR of obesity and abdominal adiposity, as well as other CVD risk factors, were significantly lower among the vegetarian groups. Similar results were found when limiting analyses to participants not being treated for CVD risk factors, with the vegans having the lowest mean BMI and waist circumference. Thus, compared with the diet of NV, vegetarian diets were associated with significantly lower levels of CVD risk factors among the non-Hispanic whites.

Indexed as

Abdominal FatAgedBody Mass IndexCardiovascular DiseasesCholesterolCholesterol, LDLDietDiet, VeganDiet, VegetarianFemaleHumansHypertensionMaleMiddle AgedObesityPrevalenceCholesterolCholesterol, LDLAdventist Health Study-2AHS-2, Adventist Health Study-2Bio-MRS, Biologic Manifestations of Religion StudyBP, blood pressureCardiovascular risk factorsDBP, diastolic blood pressureDietsDisease prevalenceDM, diabetes mellitusEPIC, European Prospective Investigation into Cancer and NutritionFBG, fasting blood glucoseHDL-C, HDL-cholesterolHR, hazard ratioLDL-C, LDL-cholesterolLipidsLOV, lacto-ovo-vegetarianMDS, Mediterranean Diet ScoreNV, non-vegetarianPR, prevalence ratioPV, pesco-vegetarianSBP, systolic blood pressureTC, total cholesterolVegetarian dietary patternsVG, veganWC, waist circumference

Identifiers

PMID30828449
PMCPMC6391580
OpenAlexW2916979860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.