ArticleComputational and structural biotechnology journal2019
Protein structure aids predicting functional perturbation of missense variants in
Article in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Structural Evaluation ofCirculation. Genomic and precision medicine · 2026Article
- Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine.Nature reviews. Cardiology · 2026Review
- Classification models distinguish functional and trafficking effects of KCNQ1 variants to enhance variant interpretation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Continuous Bayesian variant interpretation accounts for incomplete penetrance among Mendelian cardiac channelopathies.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- Predicting the functional impact of KCNQ1 variants with artificial neural networks.PLoS computational biology · 2022Article
- Estimating the Posttest Probability of Long QT Syndrome Diagnosis for RareCirculation. Genomic and precision medicine · 2021Article
- High-Throughput Reclassification of SCN5A Variants.American journal of human genetics · 2020Article
- A Bayesian method to estimate variant-induced disease penetrance.PLoS genetics · 2020Article
- Deep Mutational Scan of anCirculation. Genomic and precision medicine · 2020Article
- Structure-function relationship of the slow delayed rectifier channel: impactful questions in 2020 and beyond.American journal of physiology. Heart and circulatory physiology · 2020Article
- Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.Frontiers in pharmacology · 2020Review
- Genotype-Phenotype Correlation in a Family with Brugada Syndrome Harboring the Novel p.Gln371* Nonsense Variant in theInternational journal of molecular sciences · 2019Article
- Computational identification of vesicular transport proteins from sequences using deep gated recurrent units architecture.Computational and structural biotechnology journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Rare variants in the cardiac potassium channel K
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.