ReviewCurrent therapeutic research, clinical and experimental2019
Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris.
Review in Current therapeutic research, clinical and experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- After the green light: Evaluating drugs in Phase IV studies.Indian journal of pharmacology · 2026Review
- Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells.SLAS technology · 2026Article
- Supersaturated Isotretinoin: Scrutiny into Solid States Attributes.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Article
- Nightmares caused by isotretinoin in treating hidradenitis suppurativa: a case report and clinical insights.Dermatology reports · 2025Article
- The Perception of Contraceptive Practice Among Female Patients Treated With Isotretinoin in Saudi Arabia.Cureus · 2024Article
- Assessing the Impact of Oral Isotretinoin on the Menstrual Cycle: A Prospective Study on Predictors of Menstrual Irregularities.Medicina (Kaunas, Lithuania) · 2024Observational
- Review
- Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances.Biochemistry and biophysics reports · 2023Review
- External Validation and Updating of a Statistical Civilian-Based Suicide Risk Model in US Naval Primary Care.JAMA network open · 2023Article
- Beyond the Surface: A Deeper Look at the Psychosocial Impacts of Acne Scarring.Clinical, cosmetic and investigational dermatology · 2023Review
- Severe Insomnia Induced by Isotretinoin Use for the Management of Acne Vulgaris: A Rare Side Effect.Cureus · 2023Article
- Isotretinoin and adverse neuropsychiatric outcomes: retrospective cohort study using routine data.The British journal of dermatology · 2022Article
- Chronic Administration of 13-cis-retinoic Acid Induces Depression-Like Behavior by Altering the Activity of Dentate Granule Cells.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Article
- Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed.Journal of affective disorders reports · 2021Article
- The Developing Cerebellum as a Target for Toxic Substances: Protective Role of Antioxidants.Cerebellum (London, England) · 2021Review
- Awareness of isotretinoin use and Saudi FDA pregnancy prevention program in Riyadh, Saudi Arabia: A cross-sectional study among female patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.Dermatology research and practice · 2020Article
- Isotretinoin-Induced Delusional Disorder, Somatic Subtype.Case reports in dermatological medicine · 2020Article
- The association of depression, loneliness and internet addiction levels in patients with acne vulgaris.BioPsychoSocial medicine · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between isotretinoin (13-cis-retinoic acid, sold under trade names including Accutane [Hoffmann-La Roche Inc, Basel, Switzerland]) and birth defects, depression, and suicide is well documented but controversial. A link to psychosis and exacerbation of bipolar symptoms is less extensively addressed in the literature.
objectiveGiven recent conceptualization of psychotic disorders as neurodevelopmental, and current interest in possible shared etiology of different neurodevelopmental disorders such as psychosis, autism, and intellectual disability, this review concurrently examines the literature on developmental (primarily teratogenic) and psychiatric side effects of isotretinoin exposure. The goal of concurrent review is to identify shared mechanisms in the literature that may inform future efforts to clarify the neurocognitive and psychiatric effects of isotretinoin exposure at different developmental stages or given different genetic backgrounds.
methodsLiterature was obtained by PubMed search for the term
resultsThe association of isotretinoin exposure with prenatal developmental toxicity is well established. Although numerous reports also link isotretinoin treatment with psychiatric side effects, this association remains controversial.
conclusionsThe extent to which isotretinoin influences pediatric and adult development and cognition, and whether and why certain individuals may be susceptible to psychiatric side effects, remains to be clarified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.