ArticleBiotechnology for biofuels2019
Light/dark cycling causes delayed lipid accumulation and increased photoperiod-based biomass yield by altering metabolic flux in oleaginous
Article in Biotechnology for biofuels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
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- Application of magnetic fields to the microalgal cultivation of Nannochloropsis oceanica.Bioprocess and biosystems engineering · 2026Article
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- A multi-omic characterization of the physiological responses to salt stress in Scenedesmus obliquus UTEX393.Communications biology · 2025Article
- Mixotrophic culture enhances fucoxanthin production in the haptophyte Pavlova gyrans.Applied microbiology and biotechnology · 2024Article
- Optimization of nutrient utilization efficiency and productivity for algal cultures under light and dark cycles using genome-scale model process control.NPJ systems biology and applications · 2023Article
- Overexpression of 18S rRNA methyltransferase CrBUD23 enhances biomass and lutein content inFrontiers in bioengineering and biotechnology · 2023Article
- The Role of Photo-Cycles in the Modulation of Growth and Biochemical Profile of Microalgae: Part I-Food Interest Compounds.Life (Basel, Switzerland) · 2022Article
- Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme.Communications biology · 2021Article
- Lipid Production Capacity of a Newly Characterized Cyanobacterial StrainIranian journal of biotechnology · 2021Article
- Characterization and optimization of endogenous lipid accumulation inBiotechnology for biofuels · 2019Article
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Authors and funding
6 authors.
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Abstract
backgroundLight/dark cycling is an inevitable outdoor culture condition for microalgal biofuel production; however, the influence of this cycling on cellular lipid production has not been clearly established. The general aim of this study was to determine the influence of light/dark cycling on microalgal biomass production and lipid accumulation. To achieve this goal, specific causative mechanisms were investigated using a metabolomics approach. Laboratory scale photoautotrophic cultivations of the oleaginous green microalga
resultsLipid accumulation and carbohydrate degradation were delayed under the LD condition compared with that under the LL condition. Metabolomic analysis revealed accumulation of phosphoenolpyruvate and decrease of glycerol 3-phosphate under the LD condition, suggesting that the imbalance of these metabolites is a source of delayed lipid accumulation. When accounting for light dosage, biomass yield under the LD condition was significantly higher than that under the LL condition. Dynamic metabolic profiling showed higher levels of lipid/carbohydrate anabolism (including production of 3-phosphoglycerate, fructose 6-phosphate, glucose 6-phosphate, phosphoenolpyruvate and acetyl-CoA) from CO
conclusionsPhotoperiods define lipid accumulation and biomass production, and light/dark cycling was determined as a critical obstacle for lipid production in JSC4. Conversions of phosphoenolpyruvate to pyruvate and 3-phosphoglycerate to glycerol 3-phosphate are the candidate rate-limiting steps responsible for delayed lipid accumulation. The accumulation of substrates including ribulose 5-phosphate could be explained by the close relationship of increased biomass yield with enhanced CO
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