Evidence map›Paper›PMID 30828355›Full record

ArticleJournal of occupational medicine and toxicology (London, England)2019

New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study.

Matthias Möhner, Yimeng Liu, Gary M Marsh

Abstract read
In one paragraph

Article in Journal of occupational medicine and toxicology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Matthias Möhner1Federal Institute for Occupational Safety and Health, Berlin, Germany.
Yimeng Liu2Center for Occupational Biostatistics and Epidemiology and Department of Biostatistics, 7120 Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261 USA.
Gary M Marsh2Center for Occupational Biostatistics and Epidemiology and Department of Biostatistics, 7120 Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndications were found that a diagnostic bias could have contributed to the National Cancer Institute's (NCI) suggestion of a persistent increased mortality risk for nasopharyngeal cancer (NPC).

methodsNCI provided the cohort data updated through 2004. We computed local county rate-based standardized mortality ratios (SMRs) for NPC and all other entities of the pharynx for two time periods. Moreover, SMRs were calculated for pharyngeal cancer in relation to study site by cumulative exposure to formaldehyde (FA).

resultsOverall, our results corroborate the indications of a diagnostic bias by strong but contrary temporal trends for NPC and pharynx, not specified. Moreover, it was shown that mortality risks were increased in the Wallingford cohort for all pharyngeal cancer combined and for pharyngeal cancer excluding NPC. In contrast, no increased risks for these categories were found in the nine other study sites combined.

conclusionsOur re-analysis provided little or no evidence to support NCI's suggestion of a persistent association between FA exposure and mortality from NPC.

Indexed as

Cohort mortality studyFormaldehydeNasopharyngeal cancerNational Cancer InstituteOccupational healthRe-analyses

Identifiers

PMID30828355
PMCPMC6383225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.