ReviewFrontiers in human neuroscience2019
Genes, Cells and Brain Areas of Intelligence.
Review in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intelligence, motoric and psychological outcomes in children from different ART treatments: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2023Pooled it
- The Genetic Origin of Uneven Cognitive Profiles in Heritable Neurodevelopmental Conditions and Individual Differences: Computational Investigations.Developmental science · 2026Article
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities.Scientific reports · 2025Article
- Article
- Intelligence and Moral Development: A Critical Historical Review and Future Directions.Journal of Intelligence · 2025Review
- Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.PloS one · 2025Article
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- Gray and White Matter Metrics Demonstrate Distinct and Complementary Prediction of Differences in Cognitive Performance in Children: Findings from ABCD (The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- Grey and white matter metrics demonstrate distinct and complementary prediction of differences in cognitive performance in children: Findings from ABCD (N= 11 876).bioRxiv : the preprint server for biology · 2023Article
- Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.Nature communications · 2023Article
- Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community.Communications biology · 2023Article
- Influence of HIV infection on cognition and overall intelligence in HIV-infected individuals: advances and perspectives.Frontiers in behavioral neuroscience · 2023Review
- An economic model and evidence of the evolution of human intelligence in the Middle Pleistocene: Climate change and assortative mating.PloS one · 2023Article
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- Article
- Article
- Fluid intelligence and the locus coeruleus-norepinephrine system.Proceedings of the National Academy of Sciences of the United States of America · 2021Review
- Are Sex Differences in Human Brain Structure Associated With Sex Differences in Behavior?Psychological science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
What is the neurobiological basis of human intelligence? The brains of some people seem to be more efficient than those of others. Understanding the biological foundations of these differences is of great interest to basic and applied neuroscience. Somehow, the secret must lie in the cells in our brain with which we think. However, at present, research into the neurobiology of intelligence is divided between two main strategies: brain imaging studies investigate macroscopic brain structure and function to identify brain areas involved in intelligence, while genetic associations studies aim to pinpoint genes and genetic loci associated with intelligence. Nothing is known about how properties of brain cells relate to intelligence. The emergence of transcriptomics and cellular neuroscience of intelligence might, however, provide a third strategy and bridge the gap between identified genes for intelligence and brain function and structure. Here, we discuss the latest developments in the search for the biological basis of intelligence. In particular, the recent availability of very large cohorts with hundreds of thousands of individuals have propelled exciting developments in the genetics of intelligence. Furthermore, we discuss the first studies that show that specific populations of brain cells associate with intelligence. Finally, we highlight how specific genes that have been identified generate cellular properties associated with intelligence and may ultimately explain structure and function of the brain areas involved. Thereby, the road is paved for a cellular understanding of intelligence, which will provide a conceptual scaffold for understanding how the constellation of identified genes benefit cellular functions that support intelligence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.