ArticleJournal of clinical orthopaedics and trauma
Effects of tranexamic acid on reducing blood loss in pelvic trauma: A randomised double-blind placebo controlled study.
Article in Journal of clinical orthopaedics and trauma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint replacement for hip, pelvic and long bone fractures.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Is It Safe to Use Tranexamic Acid for Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.Asian journal of neurosurgery · 2025Review
- Review
- Effectiveness and Safety of Tranexamic Acid Use in Acute Traumatic Injury in the Prehospital and In-hospital Settings: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021Article
- [Research progress on tranexamic acid in traumatic orthopedic surgery].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManagement of pelvic trauma is complicated with patients' instability and remains high in skeletal injuries. The patients usually are young and in middle age and the management of bleeding is more important. The aim of this study is to assess the effects of Tranexamic Acid in Reducing Blood Loss in pelvic trauma: A Randomised Double-Blind Placebo Controlled Study. METHOD AND MATERIALS: In this randomized clinical trial study 106 patients with Pelvic Trauma (PT) were randomly divided into two groups. The case group received 1 g Intravenous TXA for loading dose and 3 dose per 8 h for the maintenance and control group received only serum 0.9% N.S (Normal Saline) or placebo. The Hemoglobin (Hb), Hematocrit (HCT), Pulse Rate (PR) and Blood Pressure (BP) was checked at admission, 24 h, 48 h and 72 h after admission.
resultsFrom 106 patients 61(%57.54) male and 45 (%42.46) female patients enrolled to the study. The mean age was 48.14 ± 13.54 and the range was 18-60 years old. There was no difference between two groups based on Blood Pressure at admission, 24 h, 48 h and 72 h after admission. There was a significant difference between two groups in 24 h, 48 h and 72 h after admission based on Hb and HCT amount.
conclusionbased on our findings it appears that TXA can reduce bleeding amount in the first, second and third 24 h after surgery based on Hb and HCT without any effect on systolic and diastolic BP and PR. In other hand no side effect reported by any patients.
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