Evidence map›Paper›PMID 30828130›Full record

ArticleChemistry of materials : a publication of the American Chemical Society2018

Small-Molecule Patterning via Prefunctionalized Alkanethiols.

Huan H Cao, Nako Nakatsuka, Stephanie Deshayes, John M Abendroth, Hongyan Yang, Paul S Weiss, Andrea M Kasko, Anne M Andrews

Open access · greenAbstract read
In one paragraph

Article in Chemistry of materials : a publication of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Understanding the Two-Dimensional Mixing Behavior of 1-Naphthalenethiol and Octanethiol.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Huan H Cao *Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0002-5301-3134
Nako Nakatsuka *Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0001-8248-5248
Stephanie DeshayesDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States.
John M AbendrothDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0002-2369-4311
Hongyan YangDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Paul S WeissDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0001-5527-6248
Andrea M KaskoCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0003-2355-6258
Anne M AndrewsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, United States.ORCID 0000-0002-1961-4833
California NanoSystems Institute · USUniversity of California, Los Angeles · US

Funding

Micro- to Nanoscale Neurochemical SensorsR01DA045550 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDREWS, ANNE MILASINCIC · 2017 to 2021
$5.8M
PHOTOTUNABLE BIOMATERIALS TO ENGINEER COMPLEX 3D CELL MICROENVIRONMENTSDP2OD008533 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASKO, ANDREA MARIE · 2011 to 2011
$2.3M
NIDA NIH HHS R01 DA045550NIH HHS DP2 OD008533
6 · The paper itself

Abstract

Interactions between small molecules and biomolecules are important physiologically and for biosensing, diagnostic, and therapeutic applications. To investigate these interactions, small molecules can be tethered to substrates through standard coupling chemistries. While convenient, these approaches co-opt one or more of the few small-molecule functional groups needed for biorecognition. Moreover, for multiplexing, individual probes require different surface functionalization chemistries, conditions, and/or protection/deprotection strategies. Thus, when placing multiple small-molecules on surfaces, orthogonal chemistries are needed that preserve all functional groups and are sequentially compatible. Here, we approach high-fidelity small-molecule patterning by coupling small-molecule neurotransmitter precursors, as examples, to monodisperse asymmetric oligo(ethylene glycol)alkanethiols during synthesis and

Indexed as

biorecognitionchemical patterningfluorescence microscopylithographyneurotransmitterself-assembly

Identifiers

PMID30828130
PMCPMC6393937
OpenAlexW2803812864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.