ArticleJournal of crystal growth2011
Amelogenin as a Promoter of Nucleation and Crystal Growth of Apatite.
Article in Journal of crystal growth, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Empirical and theoretical insights into the structural effects of selenite doping in hydroxyapatite and the ensuing inhibition of osteoclasts.Materials science & engineering. C, Materials for biological applications · 2020Article
- Visualizing Different Crystalline States during the Infrared Imaging of Calcium Phosphates.Vibrational Spectroscopy · 2020Article
- The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat-Protein Template Constructs.Materials (Basel, Switzerland) · 2020Review
- Mechanism of formation governs the mechanism of release of antibiotics from calcium phosphate nanopowders and cements in a drug-dependent manner.Journal of materials chemistry. B · 2019Article
- Nonlinear Oscillatory Dynamics of the Hardening of Calcium Phosphate Bone Cements.RSC advances · 2017Article
- When 1+1>2: Nanostructured composites for hard tissue engineering applications.Materials science & engineering. C, Materials for biological applications · 2015Review
- Amelogenin in Enamel Tissue Engineering.Advances in experimental medicine and biology · 2015Article
- Nanoparticulate drug delivery platforms for advancing bone infection therapies.Expert opinion on drug delivery · 2014Review
- A novel self-assembled oligopeptide amphiphile for biomimetic mineralization of enamel.BMC biotechnology · 2014Article
- CHEMICAL REACTIONS ASThe Journal of materials education · 2014Article
- The flexible structure of the K24S28 region of Leucine-Rich Amelogenin Protein (LRAP) bound to apatites as a function of surface type, calcium, mutation, and ionic strength.Frontiers in physiology · 2014Article
- Revisiting the Fundamentals in the Design and Control of Nanoparticulate Colloids in the Frame of Soft Chemistry.Review journal of chemistry · 2013Article
- Dynamic Light Scattering Based Microelectrophoresis: Main Prospects and Limitations.Journal of dispersion science and technology · 2012Article
- Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils.Biomacromolecules · 2012Article
- Novel amelogenin-releasing hydrogel for remineralization of enamel artificial caries.Journal of bioactive and compatible polymers · 2012Article
- Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro.Archives of oral biology · 2011Article
- Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols.Journal of bionic engineering · 2011Article
- Amelogenin and Enamel Biomimetics.Journal of materials chemistry. BArticle
- The Role of Hydroxyl Channel in Defining Selected Physicochemical Peculiarities Exhibited by Hydroxyapatite.RSC advancesArticle
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Authors and funding
3 authors.
Funding
Abstract
Human dental enamel forms over a period of 2 - 4 years by substituting the enamel matrix, a protein gel mostly composed of a single protein, amelogenin with fibrous apatite nanocrystals. Self-assembly of amelogenin and the products of its selective proteolytic digestion are presumed to direct the growth of apatite fibers and their organization into bundles that eventually comprise the mature enamel, the hardest tissue in the mammalian body. This work aimed to establish the physicochemical and biochemical conditions for the growth of apatite crystals under the control of a recombinant amelogenin matrix (rH174) in combination with a programmable titration system. The growth of apatite substrates was initiated in the presence of self-assembling amelogenin particles. A series of constant titration rate experiments was performed that allowed for a gradual increase of the calcium and/or phosphate concentrations in the protein suspensions. We observed a significant amount of apatite crystals formed on the substrates following the titration of rH174 sols that comprised the initial supersaturation ratio equal to zero. The protein layers adsorbed onto the substrate apatite crystals were shown to act as promoters of nucleation and growth of calcium phosphates subsequently grown on the substrate surface. Nucleation lag time experiments have showed that rH174 tends to accelerate precipitation from metastable calcium phosphate solutions in proportion to its concentration. Despite their mainly hydrophobic nature, amelogenin nanospheres, the size and surface charge properties of which were analyzed using dynamic light scattering, acted as a nucleating agent for the crystallization of apatite. The biomimetic experimental setting applied in this study proves as convenient for gaining insight into the fundamental nature of the process of amelogenesis.
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