Evidence map›Paper›PMID 30828089›Full record

ArticleThe Canadian journal of hospital pharmacy

Drug Shortages in Canada and Selected European Countries: A Cross-Sectional, Institution-Level Comparison.

Manon Videau, Lotfi Chemali, Cyril Stucki, Mar Saavedra-Mitjans, Samuel Largana, Aurélie Guerin, Pascal Bonnabry, Blaise Delhauteur, Thierry Van Hees, Denis Lebel and 1 more

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Article in The Canadian journal of hospital pharmacy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Medicine shortages in France: a 6-year retrospective study in a university medical centre.European journal of hospital pharmacy : science and practice · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Proposal for Handling of Medicine Shortages Based on a Comparison of Retrospective Risk Analysis.International journal of environmental research and public health · 2022
    Review
  9. The Canadian journal of hospital pharmacy · 2021
    Article
  10. Review
  11. The Canadian journal of hospital pharmacy · 2021
    Article
  12. Article
  13. Article
  14. Drug Shortages: More than Just Background Noise.The Canadian journal of hospital pharmacy
    Article
  15. The Canadian journal of hospital pharmacy
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manon Videauis a PharmD candidate with the Faculty of Pharmacy (ISPB), Université Claude Bernard Lyon 1, Lyon, France, and a Research Assistant with the Pharmacy Practice Research Unit, Pharmacy Department, Centre hospitalier universitaire Sainte-Justine, Montréal, Quebec.
Lotfi Chemaliis a PharmD candidate with the Faculty of Pharmacy, Université Paris Descartes, and is also a student intern with the Pharmacy Service, Hôpital Necker-Enfants malades, Paris, France.
Cyril Stucki, DPharm, is a Pharmacist with the Pharmacy Service, Hôpitaux universitaires de Genève, Geneva, Switzerland.
Mar Saavedra-Mitjans, DPharm, was, at the time of this study a Pharmacist with the Pharmacy Service, Hôpital de Santa Creu i Sant Pau, Barcelona, Spain.
Samuel Largana, DPharm, is a Pharmacist and specialist candidate in hospital pharmacy with the Pharmacy Service, Centre hospitalier régional de la Citadelle, Liège, Belgium.
Aurélie Guerin, DPharm, is a Pharmacist with the Pharmacy Service, Hôpital Necker-Enfants malades, Paris, France.
Pascal Bonnabry, DPharm, is Pharmacist and Head of the Pharmacy Service, Hôpitaux universitaires de Genève, Geneva, Switzerland.
Blaise Delhauteur, DPharm, is Pharmacist and Head of the Pharmacy Service, Centre hospitalier régional de la Citadelle, Liège, Belgium.
Thierry Van Hees, DPharm, is Pharmacist and Head of Clinical Pharmacy Services, Université de Liège, Liège, Belgium.
Denis Lebel, BPharm, MSc, FCSHP, is Assistant Director of Patient Care, Teaching and Research, Pharmacy Practice Research Unit, Pharmacy Department, Centre hospitalier universitaire Sainte-Justine, Montréal, Quebec.
Jean-François Bussières, BPharm, MSc, MBA, FCSHP, FOPQ, is Head, Pharmacy Practice Research Unit, Pharmacy Department, Centre hospitalier universitaire Sainte-Justine, and Clinical Professor, Faculty of Pharmacy, Université de Montréal, Montréal, Quebec.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug shortages represent a complex global problem affecting patients and health care professionals on a daily basis.

objectivesTo identify, describe, and compare drug shortages in health care facilities in Canada and 4 European countries in early 2018.

methodsA descriptive cross-sectional study was conducted in 1 hospital in each of 5 countries: Canada, France, Belgium, Spain, and Switzerland. Over a 4-week period, shortage data were collected daily by each hospital using a standardized grid and a standard process.

resultsFrom January 8 to February 2, 2018, there were a total of 84 shortages (median duration 32 days) in the Canadian hospital, 62 shortages (median duration 9 days) in the French hospital, 46 shortages (median duration 37 days) in the Belgian hospital, 28 shortages (median duration 25 days) in the Spanish hospital, and 98 shortages (median duration 68 days) in the Swiss hospital. The number of manufacturers implicated in the shortages was 28 for the Canadian hospital, 30 for the French hospital, 19 for the Belgian hospital, 16 for the Spanish hospital, and 42 for the Swiss hospital. Most of the shortages involved parenteral drugs, with both innovative and generic manufacturers being affected. Most therapeutic classes were affected by shortages to some extent, with the top 3 classes being anti-infective agents (accounting for 21.1% of shortages overall), central nervous system drugs (11.3%), and cardiovascular drugs (8.2%).

conclusionsDrug shortages occurred almost daily in all of the study hospitals. Across the 5 hospitals, the frequency of shortages varied by a factor of 3, which may imply similar variability at the national level. All stakeholders should work more diligently to prevent and manage drug shortages.

Indexed as

drug shortagesdrug supplypharmaceutical practice

Identifiers

PMID30828089
PMCPMC6391245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.