Evidence map›Paper›PMID 30828007›Full record

ArticleJournal of atherosclerosis and thrombosis2019

Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population.

Jing Song, Xia Jiang, Yaying Cao, Juan Juan, Tao Wu, Yonghua Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Does eating eggs matter?Archives of endocrinology and metabolism · 2022
    Review
  5. Nutritional Viewpoints on Eggs and Cholesterol.Foods (Basel, Switzerland) · 2021
    Review
  6. Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China.International journal of environmental research and public health · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing SongDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University.
Xia JiangProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health.
Yaying CaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University.
Juan JuanDepartment of Obstetrics and Gynecology, Peking University First Hospital.
Tao WuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University.
Yonghua HuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimATP-binding cassette A1 (ABCA1) plays an important role in reducing the risk of stroke. Egg is the major source of dietary cholesterol and is known to be associated with the risk of stroke and atherosclerosis. We aimed to assess the effects of interaction between an ABCA1 variant (rs2066715) and egg consumption on the risk of ischemic stroke (IS), carotid plaque, and carotid-intima media thickness (CIMT) in the Chinese population.

methodsIn total, 5869 subjects (including 1213 IS cases) across 1128 families were enrolled and divided into two groups based on the median egg consumption (4 eggs per week). In the analyses for the presence of carotid plaque and CIMT, 3171 out of 4656 IS-free controls without self-reported history of coronary heart disease and lipid-lowering medications were included. Multilevel logistic regression models were used to model the genetic association of rs2066715 with the risk of IS, and mixed-effect linear regression for the genetic association of rs2066715 with carotid plaque, and CIMT. The gene-by-egg cross-product term was included in the regression model for interaction analysis.

resultsWe found that rs2066715 was associated with the increased risk of carotid plaque among those who consumed ＜4 eggs per week after adjustment (odds ratio [95% confidence interval]: 1.61 [1.08, 2.39], P =0.019). A significant effect of interaction between rs2066715 and egg consumption on the risk of carotid plaque was identified (P =0.011).

conclusionrs2066715 was found to interact with egg consumption in modifying the risk of carotid plaque in the Chinese population.

Indexed as

Asian PeopleATP Binding Cassette Transporter 1Brain IschemiaCarotid Artery DiseasesCase-Control StudiesDietEggsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisStrokeABCA1 protein, humanATP Binding Cassette Transporter 1ATP-binding cassette A1Carotid plaqueEgg consumptionInteractionIschemic stroke

Identifiers

PMID30828007
PMCPMC6753237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.