Evidence map›Paper›PMID 30827928›Full record

ArticleEBioMedicine2019

NCR

Yonghao Liu, Yuan Song, Dandan Lin, Lei Lei, Yu Mei, Ziqi Jin, Huanle Gong, Ying Zhu, Bo Hu, Yinsheng Zhang and 8 more

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
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  3. IDH1 Mutant Glioma Favors Group 3 Innate Lymphoid Cells and Is Resistant to Immune Checkpoint Expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  9. Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Yonghao LiuInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China; Cyrus Tang Hematology Center, Soochow University, Suzhou 215123, China.
Yuan SongImmunology Programme, Life Sciences Institute and Department of Microbiology and Immunology, National University of Singapore, Singapore 117456, Singapore.
Dandan LinInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Lei LeiInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Yu MeiImmunology Programme, Life Sciences Institute and Department of Microbiology and Immunology, National University of Singapore, Singapore 117456, Singapore.
Ziqi JinInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Huanle GongInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Ying ZhuInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Bo HuInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Yinsheng ZhangInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Lixiang ZhaoInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China.
Huey Yee TeoImmunology Programme, Life Sciences Institute and Department of Microbiology and Immunology, National University of Singapore, Singapore 117456, Singapore.
Ju QiuThe Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Wen JiangDepartment of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chen DongInstitute of Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.
Depei WuInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215006, China. Electronic address: wudepei@suda.edu.cn.
Yuhui HuangCyrus Tang Hematology Center, Soochow University, Suzhou 215123, China. Electronic address: huangyh@suda.edu.cn.
Haiyan LiuImmunology Programme, Life Sciences Institute and Department of Microbiology and Immunology, National University of Singapore, Singapore 117456, Singapore. Electronic address: micliuh@nus.edu.sg.
Soochow University · CNNational University of Singapore · SGShanghai Institutes for Biological Sciences · CNThe University of Texas Southwestern Medical Center · USTsinghua University · CN

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundInnate lymphoid cells (ILCs) are a newly discovered family of immune cells that have similar cytokine-secreting profiles as T helper cell subsets. Although ILCs are critical for host defense against infections and tissue homeostasis, their roles in tumor development are not well established.

methodsWe studied the function of ILC3 cells in the liver for the development of hepatocellular carcinoma (HCC) in murine HCC models using flow cytometry, adoptive transfer, and in vitro functional assays.

findingsWe found that ILC3 lacking the natural cytotoxicity-triggering receptor (NCR

interpretationTogether, our findings suggest that NCR

Indexed as

AnimalsApoptosisCarcinoma, HepatocellularCell DifferentiationCell Line, TumorCoculture TechniquesDisease Models, AnimalImmunity, InnateInterleukin-12Interleukin-17Interleukin-23Liver NeoplasmsLymphocytesMiceMice, Inbred C57BLMice, KnockoutInterleukin-12Interleukin-17Interleukin-23Protein SubunitsHCCIL-17IL-23ILCTumor microenvironment

Identifiers

PMID30827928
PMCPMC6443584
OpenAlexW2918877774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.