Evidence map›Paper›PMID 30827897›Full record

ArticleDevelopmental cell2019

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.

Suresh Kumar, Yuexi Gu, Yakubu Princely Abudu, Jack-Ansgar Bruun, Ashish Jain, Farzin Farzam, Michal Mudd, Jan Haug Anonsen, Tor Erik Rusten, Gary Kasof and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Guideline
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  4. Programmed cell death in lung cancer: mechanisms, immune responses, and therapeutics.Apoptosis : an international journal on programmed cell death · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Suresh KumarAutophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Yuexi GuAutophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Yakubu Princely AbuduMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, The Arctic University of Norway, Tromsø 9037, Norway.
Jack-Ansgar BruunMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, The Arctic University of Norway, Tromsø 9037, Norway.
Ashish JainDepartment of Molecular Cell Biology, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0379, Norway.
Farzin FarzamDepartments of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USA.
Michal MuddAutophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Jan Haug AnonsenDepartment of Biosciences IBV Mass Spectrometry and Proteomics Unit, University of Oslo, Oslo 0371, Norway.
Tor Erik RustenDepartment of Molecular Cell Biology, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0379, Norway.
Gary KasofCell Signaling Technology, Danvers, MA 01923, USA.
Nicholas KtistakisSignalling Programme, The Babraham Institute, Cambridge CB22 3AT, UK.
Keith A LidkeDepartments of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USA.
Terje JohansenMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, The Arctic University of Norway, Tromsø 9037, Norway.
Vojo DereticAutophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. Electronic address: vderetic@salud.unm.edu.
University of New Mexico · USUiT The Arctic University of Norway · NOUniversity of Oslo · NOBabraham Institute · GBCell Signaling Technology (United States) · USNorwegian Cancer Society · NO

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2017 to 2026
$24.9M
Autophagy Against Tuberculosis and HIVR01AI111935 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P · 2014 to 2023
$7.0M
Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSR01AI042999 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P · 1998 to 2017
$6.6M
Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSR37AI042999 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2018 to 2026
$4.7M
Biotechnology and Biological Sciences Research Council BB/K019155/1Biotechnology and Biological Sciences Research Council BBS/E/B/000C0413NIAID NIH HHS R01 AI042999NIAID NIH HHS R01 AI111935NIAID NIH HHS R37 AI042999NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the ATG13

Indexed as

Adaptor Proteins, Signal TransducingAutophagosomesAutophagyAutophagy-Related ProteinsGene Knockout TechniquesGolgi ApparatusHEK293 CellsHeLa CellsHumansLysosomesMembrane FusionMultiprotein ComplexesMutationPhosphorylationProtein Serine-Threonine KinasesProtein-Tyrosine KinasesAdaptor Proteins, Signal TransducingATG13 protein, humanAutophagy-Related ProteinsMultiprotein ComplexesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesQa-SNARE ProteinsRB1CC1 protein, humanSTX17 protein, humanTBK1 protein, humanautophagypre-autophagosomal structureTBK1ULK1

Identifiers

PMID30827897
PMCPMC6907693
OpenAlexW2918344400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.