ArticleCell metabolism2019
Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron.
Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Obesity in Adults: A 2022 Adapted Clinical Practice Guideline for Ireland.Obesity facts · 2022Guideline
- Obesity in adults: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020 · on this mapGuideline
- Trial
- Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial.Clinical obesity · 2025Trial
- Article
- Internal Circadian Misalignment of the Human Metabolome Links Night Shiftwork to Metabolic Impairment.Journal of biological rhythms · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Gut Microbiome in Obesity: A Narrative Review of Mechanisms, Interventions, and Future Directions.Probiotics and antimicrobial proteins · 2026Review
- Review
- The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation.Translational psychiatry · 2026Article
- Article
- The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition.Nature communications · 2026Article
- The Drosophila SIFamide Receptor Regulates Sleep and Feeding in a Time-Of-Day Specific Manner.Genes, brain, and behavior · 2025Article
- Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- The metabolic significance of peripheral tissue clocks.Communications biology · 2025Review
- Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?Current obesity reports · 2025Review
- Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body.Molecular metabolism · 2025Article
- The role of vitamin D in sleep regulation: mechanisms, clinical advances, and future directions.Frontiers in nutrition · 2025Review
- Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake.Science (New York, N.Y.) · 2024Article
- Fasting-induced activity changes in MC3R neurons of the paraventricular nucleus of the thalamus.Life science alliance · 2024Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
The alignment of fasting and feeding with the sleep/wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons. Tandem profiling of whole-cell and ribosome-bound mRNAs in morning and evening under dynamic fasting and fed conditions identified temporal control of activity-dependent gene repertoires in AgRP neurons central to synaptogenesis, bioenergetics, and neurotransmitter and peptidergic signaling. Synaptic and circadian pathways were specific to whole-cell RNA analyses, while bioenergetic pathways were selectively enriched in the ribosome-bound transcriptome. Finally, we demonstrate that the AgRP clock mediates the transcriptional response to leptin. Our results reveal that time-of-day restriction in transcriptional control of energy-sensing neurons underlies the alignment of hunger and food acquisition with the sleep/wake state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.