ArticleChinese journal of traumatology = Zhonghua chuang shang za zhi2019
The wound healing potential of collagen peptides derived from the jellyfish Rhopilema esculentum.
Article in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review.Marine biotechnology (New York, N.Y.) · 2021Pooled it
- Peptides from Animal Origin: A Systematic Review on Biological Sources and Effects on Skin Wounds.Oxidative medicine and cellular longevity · 2020Pooled it
- Bioaccumulation and Toxicity of Tritiated Water in Jellyfish.ACS environmental Au · 2026Article
- Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti-inflammatory, and Wound-Healing Activities of Endophytic Fungi Isolated From Atalantia racemosa.Chemistry & biodiversity · 2026Article
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.Nutrients · 2026Review
- Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026Article
- Antioxidant, Anti-Inflammatory and Anticancer Peptides from Extreme Marine Environments.Antioxidants (Basel, Switzerland) · 2026Review
- Isolation, Characterization and Biological Evaluation of Collagen fromMarine drugs · 2026Article
- Characterization of a New Biocomposite Based on Bioactive Compounds fromPharmaceuticals (Basel, Switzerland) · 2026Article
- Ligustroside attenuates fibrosis-associated wound remodeling and suppresses fibrosis-related signaling in a rat excisional wound model.PloS one · 2026Article
- Comparative analysis of collagen from different sources for wound and burn management.Biomaterials translational · 2026Article
- Collagen from Marine Sources for Potential Application in Wound Treatment.Progress in molecular and subcellular biology · 2026Review
- The Fibrillar Collagens of Bony Fish: Genes, Proteins, and Biomedical Applications.Sub-cellular biochemistry · 2026Review
- Article
- Molecular Weight Distribution and Antioxidant Activity of Enzymatic Hydrolysates fromMarine drugs · 2025Article
- Article
- Current Insights and Future Directions in Scar Management and Skin Regeneration.International journal of molecular sciences · 2025Review
- Activation of Angiogenic TGF-β1 by Salbutamol Enhances Wound Contraction and Improves Healing in a Streptozotocin-Induced Diabetic Rat Model.Current issues in molecular biology · 2025Article
- Effects of a single application of hydrolyzed fish collagen on dermal protein expression and tissue architecture in human skin models.Scientific reports · 2025Article
- Marine Jellyfish Collagen and Other Bioactive Natural Compounds from the Sea, with Significant Potential for Wound Healing and Repair Materials.Marine drugs · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWound represents a major health challenge as they consume a large amount of healthcare resources to improve patient's quality of life. Many scientific studies have been conducted in search of ideal biomaterials with wound-healing activity for clinical use and collagen has been proven to be a suitable candidate biomaterial. This study intended to investigate the wound healing activity of collagen peptides derived from jellyfish following oral administration.
methodsIn this study, collagen was extracted from the jellyfish--Rhopilema esculentum using 1% pepsin. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fourier transform infrared (FTIR) were used to identify and determine the molecular weight of the jellyfish collagen. Collagenase II, papain and alkaline proteinase were used to breakdown jellyfish collagen into collagen peptides. Wound scratch assay (in vitro) was done to determine migration potential of human umbilical vein endothelial cells (HUVEC) covering the artificial wound created on the cell monolayer following treatment with collagen peptides. In vivo studies were conducted to determine the effects of collagen peptides on wound healing by examining wound contraction, re-epithelialization, tissue regeneration and collagen deposition on the wounded skin of mice. Confidence level (p < 0.05) was considered significant using GraphPad Prism software.
resultsThe yield of collagen was 4.31%. The SDS-PAGE and FTIR showed that extracted collagen from jellyfish was type I. Enzymatic hydrolysis of this collagen using collagenase II produced collagen peptides (CP
conclusionCollagen peptides derived from the jellyfish-Rhopilema esculentum can accelerate the wound healing process thus could be a therapeutic potential product that may be beneficial in wound clinics in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.