Evidence map›Paper›PMID 30827796›Full record

ReviewTrends in cognitive sciences2019

Brain Modularity: A Biomarker of Intervention-related Plasticity.

Courtney L Gallen, Mark D'Esposito

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  8. Article
  9. Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.Annals of clinical and translational neurology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Courtney L GallenDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA; Neuroscape, University of California San Francisco, San Francisco, CA, USA. Electronic address: courtney.gallen@ucsf.edu.
Mark D'EspositoHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Psychology, University of California, Berkeley, Berkeley, CA, USA.

Funding

Mechanisms of Neuroplasticity in Functional Brain NetworksR01NS079698 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2013 to 2017
$1.6M
NINDS NIH HHS R01 NS079698
6 · The paper itself

Abstract

Interventions using methods such as cognitive training and aerobic exercise have shown potential to enhance cognitive abilities. However, there is often pronounced individual variability in the magnitude of these gains. Here, we propose that brain network modularity, a measure of brain subnetwork segregation, is a unifying biomarker of intervention-related plasticity. We present work from multiple independent studies demonstrating that individual differences in baseline brain modularity predict gains in cognitive control functions across several populations and interventions, spanning healthy adults to patients with clinical deficits and cognitive training to aerobic exercise. We believe that this predictive framework provides a foundation for developing targeted, personalized interventions to improve cognition.

Indexed as

BiomarkersCognitive RemediationExercise TherapyBrainCognitive DysfunctionExecutive FunctionHumansNerve NetNeuronal PlasticityBiomarkersbrain injurycognitive controlcognitive trainingexecutive functionfunctional connectivitygraph theory

Identifiers

PMID30827796
PMCPMC6750199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.