Evidence map›Paper›PMID 30827758›Full record

SynthesisDrug and alcohol dependence2019

Prenatal alcohol exposure and offspring mental health: A systematic review.

Kayleigh E Easey, Maddy L Dyer, Nicholas J Timpson, Marcus R Munafò

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 6 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 6 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kayleigh E EaseyUK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, UK; MRC Integrative Epidemiology Unit, University of Bristol, UK. Electronic address: kayleigh.easey@bristol.ac.uk.
Maddy L DyerUK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, UK; MRC Integrative Epidemiology Unit, University of Bristol, UK.
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Marcus R MunafòUK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, UK; MRC Integrative Epidemiology Unit, University of Bristol, UK.
University of Bristol · GB

Funding

Cancer Research UK C18281/A19169Medical Research Council MC_UU_00011/7Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

backgroundHigh levels of alcohol use in pregnancy have been shown to be associated with negative physical health consequences in offspring. However, the literature is less clear on the association of alcohol use in pregnancy and offspring mental health, specifically for low levels of prenatal alcohol exposure. We conducted a systematic review to evaluate studies examining this association.

methodsStudies were identified by searching PsycINFO, PubMed and Web of Science, and were included if they examined alcohol use during pregnancy as an exposure and offspring mental health at age 3 or older as an outcome. We excluded non-English language publications and studies of fetal alcohol syndrome.

resultsThirty-three studies were included and were categorized by mental health outcomes: anxiety/depression, emotional problems, total internalizing problems, total problem score, and conduct disorder. Over half of the analyses reported a positive association of prenatal alcohol exposure and offspring mental health problems.

conclusionsOur review suggests that maternal alcohol use during pregnancy is associated with offspring mental health problems, even at low to moderate levels of alcohol use. Future investigation using methods that allow stronger causal inference is needed to further investigate if these associations shown are causal.

Indexed as

Alcohol DrinkingAlcoholismChild, PreschoolFemaleHumansNeurodevelopmental DisordersPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsAlcoholIntrauterineMental healthPregnancyPrenatalSystematic review

Identifiers

PMID30827758
PMCPMC6446223
OpenAlexW2920451966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.