Evidence map›Paper›PMID 30827533›Full record

ArticleAmerican journal of surgery2019

The effects of propranolol and clonidine on bone marrow expression of hematopoietic cytokines following trauma and chronic stress.

Tyler J Loftus, Elizabeth S Miller, Jessica K Millar, Kolenkode B Kannan, Ines G Alamo, Philip A Efron, Alicia M Mohr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tyler J LoftusUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Tyler.Loftus@surgery.ufl.edu.
Elizabeth S MillerUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Elizabeth.Miller@surgery.ufl.edu.
Jessica K MillarUniversity of Florida, College of Medicine, Gainesville, FL, USA. Electronic address: jmillara5@ufl.edu.
Kolenkode B KannanUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Kolenkode.Kannan@surgery.ufl.edu.
Ines G AlamoUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: ialamo518@gmail.com.
Philip A EfronUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: philip.efron@surgery.ufl.edu.
Alicia M MohrUniversity of Florida, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: alicia.mohr@surgery.ufl.edu.
University of Florida · USFlorida College · US

Funding

PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
STUDENTS IN HEALTH PROFESSIONAL SCHOOLST35HL007489 · NHLBI · UNIVERSITY OF FLORIDA · PI Scott A Berceli, Robert Maile · 1985 to 2026
$2.4M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NHLBI NIH HHS T35 HL007489NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893NIGMS NIH HHS R01 GM113945NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundAttenuating post-injury neuroendocrine stress abrogates persistent injury-associated anemia. Our objective was to examine the mechanisms by which propranolol and clonidine modulate this process. We hypothesized that propranolol and clonidine would decrease bone marrow expression of high-mobility group box-1 (HMGB1) and increase expression of stem cell factor (SCF) and B-cell lymphoma-extra large (Bcl-xL).

methodsMale Sprague-Dawley rats were allocated to naïve control, lung contusion followed by hemorrhagic shock (LCHS), or LCHS plus daily chronic restraint stress (LCHS/CS) ±propranolol, ±clonidine. Day seven bone marrow expression of HMGB1, SCF, and Bcl-xL was assessed by polymerase chain reaction.

resultsFollowing LCHS, HMGB1 was decreased by propranolol (49% decrease, p = 0.012) and clonidine (54% decrease, p < 0.010). SCF was decreased following LCHS/CS, and was increased by propranolol (629% increase, p < 0.001) and clonidine (468% increase, p < 0.001). Bcl-xL was decreased following LCHS/CS, and was increased by propranolol (59% increase, p = 0.006) and clonidine (77% increase, p < 0.001).

conclusionsFollowing severe trauma, propranolol and clonidine abrogate persistent injury-associated anemia by modulating bone marrow cytokines, favoring effective erythropoiesis.

Indexed as

AnemiaAnimalsBiomarkersBone MarrowChronic DiseaseClonidineContusionsCytokinesDrug Therapy, CombinationErythropoiesisHematinicsLung InjuryMalePropranololRandom AllocationRatsBiomarkersClonidineCytokinesHematinicsPropranololBone marrowErythropoiesisInjuryStressTrauma

Identifiers

PMID30827533
PMCPMC6703959
OpenAlexW2916833669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.