Evidence map›Paper›PMID 30827499›Full record

ArticleAmerican journal of human genetics2019

Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure.

Guillaume Laval, Stéphane Peyrégne, Nora Zidane, Christine Harmant, François Renaud, Etienne Patin, Franck Prugnolle, Lluis Quintana-Murci

Open access · bronzeAbstract read
In one paragraph

Article in American journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  7. Redox Potential (EMolecules (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Inferring Balancing Selection From Genome-Scale Data.Genome biology and evolution · 2023
    Review
  11. New insights into human immunity from ancient genomics.Current opinion in immunology · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Guillaume LavalHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address: glaval@pasteur.fr.
Stéphane PeyrégneHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
Nora ZidaneHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France.
Christine HarmantHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France.
François RenaudLaboratory MIVEGEC (Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle), UMR 5290 Centre National de la Recherche Scientifique, Institut de Rechereche pour le Développement, Montpellier 34394, France.
Etienne PatinHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France.
Franck PrugnolleLaboratory MIVEGEC (Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle), UMR 5290 Centre National de la Recherche Scientifique, Institut de Rechereche pour le Développement, Montpellier 34394, France.
Lluis Quintana-MurciHuman Evolutionary Genetics Unit, Institut Pasteur, UMR 2000 Centre National de la Recherche Scientifique, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address: quintana@pasteur.fr.
Agropolis International · FRMaladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle · FRMax Planck Institute for Evolutionary Anthropology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hemoglobin β

Indexed as

Adaptation, PhysiologicalBiological EvolutionGenetics, PopulationSelection, GeneticAfricaAgricultureAnemia, Sickle CellBlack PeopleForestsGene FlowHemoglobin, SickleHumansIncidenceMalariaRainforestHemoglobin, SickleAfricaapproximate Bayesian computationbalancing selectionfarmersmalariarainforest hunter-gathererssickle mutation

Identifiers

PMID30827499
PMCPMC6407493
OpenAlexW2920416911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.