ArticleCerebellum (London, England)2019
Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum.
Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis.Human brain mapping · 2020Pooled it
- Transcranial alternating current stimulation for treating spinocerebellar ataxia type 3: A randomized controlled trial.Cell reports. Medicine · 2025Trial
- Age-related degradation of cerebellar functional network topology.GeroScience · 2026Article
- Article
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
- Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing.NMR in biomedicine · 2025Article
- The cerebellar-related cognitive function is sensitive to aging: implications for early detection.Frontiers in aging neuroscience · 2025Article
- Consensus Paper: Cerebellum and Ageing.Cerebellum (London, England) · 2024Review
- Non-invasive neuromodulation of cerebello-hippocampal volume-behavior relationships.bioRxiv : the preprint server for biology · 2024Article
- Editorial: Insights in neurocognitive aging and behavior: 2022.Frontiers in aging neuroscience · 2024Article
- Cerebellar EEG source localization reveals age-related compensatory activity moderated by genetic risk for Alzheimer's disease.Psychophysiology · 2023Article
- Anodal cerebellar stimulation increases cortical activation: Evidence for cerebellar scaffolding of cortical processing.Human brain mapping · 2023Article
- Utility of quantitative MRI metrics in brain ageing research.Frontiers in aging neuroscience · 2023Article
- The impact of aging on morphometric changes in the cerebellum: A voxel-based morphometry study.Frontiers in aging neuroscience · 2023Article
- Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.Neuroscience and biobehavioral reviews · 2022Review
- The Polarity-Specific Nature of Single-Session High-definition Transcranial Direct Current Stimulation to the Cerebellum and Prefrontal Cortex on Motor and Non-motor Task Performance.Cerebellum (London, England) · 2021Article
- Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.Cerebellum (London, England) · 2020Article
- Functional Changes of Mentalizing Network in SCA2 Patients: Novel Insights into Understanding the Social Cerebellum.Cerebellum (London, England) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.