SynthesisEuropean journal of pediatrics2019
Maternal blood leptin concentration in small for gestational age: a meta-analysis.
Synthesis in European journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association of high maternal blood alpha-fetoprotein level with risk of delivering small for gestational age: a meta-analysis.Pediatric research · 2021Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monitoring leptin concentration in maternal blood would be useful for earlier identification of mothers at risk of delivering small for gestational age (SGA) neonates. This study was performed to examine whether maternal blood leptin concentrations are different between SGA neonates and healthy controls. Meta-analysis was performed to summarize the data of all English-language studies providing the numbers of SGA neonates, the numbers of healthy controls, and the means and standard deviations of maternal blood leptin concentrations in these two groups. The studies were collected by searching ten databases including PubMed (MEDLINE) and investigating the PubMed Related Citations and bibliographic references. The Newcastle-Ottawa Scale was used to assess study quality. Publication bias was assessed using Egger's test. The primary outcome of this study was the standardized mean difference (SMD) in maternal blood leptin concentration between SGA neonates and healthy controls. Thirty-two overall good-quality studies involving 1734 women and their neonates were extracted from 17 articles. Synthetic evidence did not indicate statistically significant SMD in maternal blood leptin concentration between SGA neonates and healthy controls (P = 0.172). Egger's test showed no publication bias (P = 0.309).Conclusion: Maternal blood leptin concentration is not significantly different between SGA neonates and healthy controls. What is Known: • Monitoring leptin concentration in maternal blood would be useful for earlier identification of mothers at risk of delivering small for gestational age (SGA) neonates. What is New: • The results of this meta-analysis including 1734 women and their neonates in 32 overall good-quality studies showed that maternal blood leptin concentration is not significantly different between SGA neonates and healthy controls.
Indexed as
Identifiers
30826865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.