ArticleEuropean journal of pediatrics2019
Diverse cutaneous manifestation of Langerhans cell histiocytosis: a 10-year retrospective cohort study.
Article in European journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prevalence of oral lesions in Langerhans cell histiocytosis: a systematic review and meta-analysis.Oral and maxillofacial surgery · 2026Pooled it
- Cutaneous manifestations of pediatric Langerhans cell histiocytosis: A single-center case series from 2019 to 2024.JAAD case reports · 2026Article
- Infantile Cutaneous Langerhans Cell Histiocytosis Presenting as Benign Skin Lesions: Clinical Pitfalls and Diagnostic Clues.Dermatology practical & conceptual · 2026Article
- Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Congenital Langerhans Cell Histiocytosis With the Skin and Lung Involvement: A Case and Literature Review.Cureus · 2023Article
- Clinical outcomes and screening for organ involvement in pediatric Langerhans cell histiocytosis in Thailand: multicenter study on behalf of the Thai Pediatric Oncology Group.International journal of hematology · 2022Article
- Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man.JAAD case reports · 2022Article
- Langerhans cell histiocytosis: Case report and literature reviewBiomedica : revista del Instituto Nacional de Salud · 2021Review
- Clinical characteristics and outcomes of Langerhans cell histiocytosis at a single institution in Thailand: a 20-year retrospective study.Asian biomedicine : research, reviews and news · 2021Article
- Article
- Diaper rashes can indicate systemic conditions other than diaper dermatitis.BMC dermatology · 2020Article
- Childhood Langerhans cell histiocytosis: a disease with many faces.World journal of pediatrics : WJP · 2019Review
- [Histiocytosis in the dermatological context of the new classification].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2019Review
- Langerhans cell histiocytosis: a rare case of the multisystemic form in an infant.Anais brasileiros de dermatologiaArticle
- [18F]FDG- PET/CT in Diagnosis, Staging, and Management of Patients with Langerhans Cell Histiocytosis.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
- Extensive Nail Changes Are a Possible Clue Indicating Multisystem Involvement in Childhood Langerhans Cell Histiocytosis: A Case Report and Literature Review.Case reports in dermatologyArticle
- A Newborn Female with a Diffuse Rash.Dermatopathology (Basel, Switzerland)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous manifestation is a common presentation of LCH and is usually a leading clue for the disease diagnosis. Having cutaneous lesions did not show a significantly early age onset at diagnosis compared to those without skin lesions, P value = 0.71. In the present study, cutaneous findings were found as 77.7%. Seborrheic dermatitis-like lesions were the most common cutaneous type (42.8%), followed by papules/nodules/masses (28.5%), petechiae/hemorrhagic lesions (17.8%), and eczematous lesions (10.7%). Time to diagnosis of LCH presented with seborrheic dermatitis-like lesions was significantly longer than other cutaneous presentations, P value = 0.0011.Conclusion: Patients with LCH who had the manifestations of seborrheic dermatitis-like lesions can have diagnosis delayed due to the difficulty in distinguishing these lesions from normal seborrheic dermatitis lesions. Petechiae/hemorrhagic cutaneous signs in addition to the normal seborrheic dermatitis is the clue for early detection of the disease. To improve early detection of LCH, general pediatricians should be alerted to be aware of these skin symptoms, and if they persist, a dermatologist, pediatric if available, should be immediately consulted. What is Known? • Cutaneous manifestation is a common presentation of LCH and is usually a leading clue for the disease diagnosis. What is New? • Patients with LCH who have the manifestations of seborrheic dermatitis-like lesions can have a delayed diagnosis due to the difficulty in distinguishing normal from seborrheic dermatitis lesions. • Petechiae/hemorrhagic cutaneous signs in addition to the normal seborrheic dermatitis are the clue to the early disease detection.
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