Evidence map›Paper›PMID 30826860›Full record

ReviewCellular and molecular life sciences : CMLS2019

Anti-inflammatory cytokines in endometriosis.

Wen-Jie Zhou, Hui-Li Yang, Jun Shao, Jie Mei, Kai-Kai Chang, Rui Zhu, Ming-Qing Li

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  9. Article
  10. Enhanced CD56 Expression and Increased Number of CD56American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
  11. Review
  12. Article
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  16. Endometriosis and the Hallmarks of Cancer.Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen-Jie ZhouLaboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China.
Hui-Li YangLaboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China.
Jun ShaoLaboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China.
Jie MeiDepartment of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Reproductive Medicine Center, The Affiliated Hospital of Nanjing University Medicine School, Nanjing, 210000, People's Republic of China.
Kai-Kai ChangDepartment of Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200011, People's Republic of China.
Rui ZhuCenter for Human Reproduction and Genetics, Suzhou Municipal Hospital, Suzhou, 215008, People's Republic of China.
Ming-Qing LiLaboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China. mqli@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9276-0722

Funding

Foundation for the Advancement in Research in Medicine (US) 021414380180Innovation-oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation CX2017-2National Natural Science Foundation of China 31600735National Natural Science Foundation of China 31671200National Natural Science Foundation of China 81471513National Natural Science Foundation of China 81571509National Natural Science Foundation of China 81601354National Natural Science Foundation of China 91542108Natural Science Foundation of Jiangsu Province BK20160128Shanghai Rising-Star Program 16QA1400800State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals (CN) 14DZ2271700
6 · The paper itself

Abstract

Although the pathogenesis of endometriosis is not fully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g., interleukin-4 and -10, and transforming growth factor-β1) occurs in women with endometriosis, including in serum, peritoneal fluid and ectopic lesions. These anti-inflammatory cytokines also have indispensable roles in the progression of endometriosis, including by promoting survival, growth, invasion, differentiation, angiogenesis, and immune escape of the endometriotic lesions. In this review, we provide an overview of the expression, origin, function and regulation of anti-inflammatory cytokines in endometriosis, with brief discussion and perspectives on their future clinical implications in the diagnosis and therapy of the disease.

Indexed as

Disease ProgressionEndometriosisEndometriumEpithelial CellsEpithelial-Mesenchymal TransitionFemaleGene Expression RegulationHumansInflammationInterleukin-10Interleukin-4Killer Cells, NaturalMacrophagesSignal TransductionStromal CellsT-LymphocytesIL10 protein, humanIL4 protein, humanInterleukin-10Interleukin-4TGFB1 protein, humanTransforming Growth Factor beta1Anti-inflammatoryCytokineEndometrial stromal cellsEndometriosisIL-10MacrophageNK cellsT cellsTGF-β

Identifiers

PMID30826860
PMCPMC11105498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.