ArticlePsychopharmacology2019
An automated home-cage-based 5-choice serial reaction time task for rapid assessment of attention and impulsivity in rats.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 66 citations in OpenAlex.
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- Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access.Alcohol (Fayetteville, N.Y.) · 2024Article
- Long Mu Qing Xin mixture improves behavioral performance in spontaneously hypertensive rats (SHR/NCrl) by upregulating catecholamine neurotransmitters in prefrontal cortex and striatum via DRD1/cAMP/PKA-CREB signaling pathway.Frontiers in pharmacology · 2024Article
- Dissection of neuronal circuits underlying sustained attention with the five-choice serial reaction time task.Neuroscience and biobehavioral reviews · 2023Review
- An automated, low-latency environment for studying the neural basis of behavior in freely moving rats.BMC biology · 2023Article
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- Dissociating motor impairment from five-choice serial reaction time task performance in a mouse model of Angelman syndrome.Frontiers in behavioral neuroscience · 2022Article
- Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum.Nature communications · 2021Article
- Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives.Frontiers in behavioral neuroscience · 2021Article
- Assessing Impulsivity in Humans and Rodents: Taking the Translational Road.Frontiers in behavioral neuroscience · 2021Review
- Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system.Scientific reports · 2020Article
- Neonatal 6-OHDA Lesion Model in Mouse Induces Cognitive Dysfunctions of Attention-Deficit/Hyperactivity Disorder (ADHD) During Young Age.Frontiers in behavioral neuroscience · 2020Article
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- Scopolamine and Medial Frontal Stimulus-Processing during Interval Timing.Neuroscience · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleThe 5-choice serial reaction time task (5-CSRTT) is a widely used operant task for measuring attention and motor impulsivity in rodents. Training animals in this task requires an extensive period of daily operant sessions. Recently, a self-paced, automated version of this task has been developed for mice, which substantially reduces training time. Whether a similar approach is effective for rats is currently unknown.
objectiveHere, we tested whether attention and impulsivity can be assessed in rats with a self-paced version of the 5-CSRTT.
methodsOperant boxes were connected to home-cages with tunnels. Two groups of rats self-paced their training by means of an automated script. The first group of animals was allowed unlimited access (UA) to start trials in the task; for the second group, trial availability was restricted to the first 2.5 h of the dark cycle (TR). Task parameter manipulations, such as variable inter-trial intervals and stimulus durations as well as pharmacological challenges with scopolamine, were tested to validate the task.
resultsSelf-paced training took less than 1 week. Animals in the UA group showed higher levels of omissions compared with the TR group. In both protocols, variable inter-trial intervals increased impulsivity, and variable stimulus durations decreased attentional performance. Scopolamine affected cognitive performance in the TR group only.
conclusionsHome-cage-based training of the 5-CSRTT in rats, especially the TR protocol, presents a valid and fast alternative for measuring attention and impulsivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.