ArticleEnvironment international2019
Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- 'Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.Environment international · 2022Pooled it
- Independent and joint air pollutants exposure associated with kidney dysfunction mediating by hematocyte.Scientific reports · 2025Article
- Joint effects of temperature and humidity with PMBMC public health · 2025Article
- Exploring the Potential of Coix Seeds to Mitigate High Humidity-Induced Gut Inflammation via Microbiota and Metabolite Modulation.Journal of inflammation research · 2025Article
- The Association Between Air Pollution Exposure and White Blood Cell Counts: A Nationwide Cross-Sectional Survey in South Korea.Journal of clinical medicine · 2024Article
- Application of exponential smoothing method and SARIMA model in predicting the number of admissions in a third-class hospital in Zhejiang Province.BMC public health · 2023Article
- The role of peripheral immunity in ALS: a population-based study.Annals of clinical and translational neurology · 2023Article
- Associations between Short-Term Air Pollution Exposure and the Peripheral Leukocyte Distribution in the Adult Male Population in Beijing, China.International journal of environmental research and public health · 2023Article
- Increased allergic and asthmatic risks in children residing in industrial areas by surveying the pre-inflammatory (IgE, IL-4 and IL-13) biomarkers.Journal of environmental health science & engineering · 2022Article
- Polysaccharides from fermented coix seed modulates circulating nitrogen and immune function by altering gut microbiota.Current research in food science · 2022Article
- Short-term exposure to high relative humidity increases blood urea and influences colonic urea-nitrogen metabolism by altering the gut microbiota.Journal of advanced research · 2022Article
- Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.International journal of molecular sciences · 2021Review
- Influence of air pollutants on varicella among adults.Scientific reports · 2021Article
- Short-term exposure to PMJournal of hazardous materials · 2021Article
- Ambient air pollution and posttransplant outcomes among kidney transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Role of atmospheric particulate matter exposure in COVID-19 and other health risks in human: A review.Environmental research · 2021Review
- The Association Pattern between Ambient Temperature Change and Leukocyte Counts.International journal of environmental research and public health · 2021Observational
- Hallmarks of environmental insults.Cell · 2021Review
- Effects of noise and low-concentration carbon monoxide exposure on rat immunity.Journal of occupational health · 2021Article
- High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundExploring the associations of air pollution and weather variables with blood leukocyte distribution is critical to understand the impacts of environmental exposures on the human immune system.
objectivesAs previous analyses have been mainly based on data from cell counters, which might not be feasible in epidemiologic studies including large populations of long-stored blood samples, we aimed to expand the understanding of this topic by employing the leukocyte distribution estimated by DNA methylation profiles.
methodsWe measured DNA methylation profiles in blood samples using Illumina HumanMethylation450 BeadChip from 1519 visits of 774 Caucasian males participating in the Normative Aging Study. Leukocyte distribution was estimated using Houseman's and Horvath's algorithms. Data on air pollution exposure, temperature, and relative humidity within 28 days before each blood draw was obtained.
resultsAfter fully adjusting for potential covariates, PM
conclusionsOur study suggests that short-term air pollution exposure, temperature, and relative humidity are associated with leukocyte distribution. Our study further provides a successful attempt to use epigenetic patterns to assess the influences of environmental exposures on human immune profiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.