Evidence map›Paper›PMID 30826615›Full record

ArticleEnvironment international2019

Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health.

Christine Ladd-Acosta, Jason I Feinberg, Shannon C Brown, Frederick W Lurmann, Lisa A Croen, Irva Hertz-Picciotto, Craig J Newschaffer, Andrew P Feinberg, M Daniele Fallin, Heather E Volk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Prenatal PMNature communications · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Environmental Pollution and Reproductive Health: The Cause for Concern.Journal of obstetrics and gynaecology of India · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: claddac1@jhu.edu.
Jason I FeinbergWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Shannon C BrownDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Frederick W LurmannSonoma Technology, Inc., Petaluma, CA, USA.
Lisa A CroenAutism Research Program, Division of Research, Kaiser Permanente, Oakland, CA, USA.
Irva Hertz-PicciottoDepartment of Public Health Sciences, MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, University of California, Davis, CA, USA.
Craig J NewschafferA.J. Drexel Autism Institute and Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA.
Andrew P FeinbergDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
M Daniele FallinWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Heather E VolkWendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Johns Hopkins University · USCenter for Autism and Related Disorders · USDrexel University · USJohns Hopkins Medicine · USKaiser Permanente · USSonoma Technology (United States) · USUniversity of California, Davis · US

Funding

Early Autism Risk Longitudinal Investigation (EARLI) NetworkR01ES016443 · NIEHS · DREXEL UNIVERSITY · PI NEWSCHAFFER, CRAIG J · 2008 to 2013
$15.6M
Environment, The Perinatal Epigenome, and Risk for Autism and Related DisordersR01ES017646 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE, FEINBERG, ANDREW P. · 2009 to 2013
$8.7M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Prospective Evaluation of Air Pollution, Cognition, and Autism from Birth OnwardR01ES023780 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VOLK, HEATHER E · 2014 to 2017
$3.0M
Autism Speaks AS7785NIEHS NIH HHS R01 ES016443NIEHS NIH HHS R01 ES017646NIEHS NIH HHS R01 ES023780NIEHS NIH HHS R01 ES025531
6 · The paper itself

Abstract

backgroundPrenatal air pollution exposure has been linked to many adverse health conditions in the offspring. However, little is known about the mechanisms underlying these associations. Epigenetics may be one plausible biologic link. Here, we sought to identify site-specific and global DNA methylation (DNAm) changes, in developmentally relevant tissues, associated with prenatal exposure to nitrogen dioxide (NO

methodsGenome-scale DNAm measurements were obtained using the Infinium HumanMethylation450k platform for 133 placenta and 175 cord blood specimens from Early Autism Risk Longitudinal Investigation (EARLI) neonates. Ambient NO

resultsWe identified global and locus-specific changes in DNA methylation related to prenatal exposure to NO

conclusionsWe observed global, locus, and sex-specific methylation changes associated with prenatal NO

Indexed as

DNA MethylationMaternal-Fetal ExchangeAir PollutantsAir PollutionChild HealthEpigenomicsFemaleHumansInfant HealthInfant, NewbornMaleMaternal ExposureNitrogen DioxideOzonePlacentaPregnancyAir PollutantsNitrogen DioxideOzoneDNA methylationEpigeneticGenome-scalePlacentaPrenatal air pollution exposureSex differences

Identifiers

PMID30826615
PMCPMC6446941
OpenAlexW2921455906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.