ArticleNeuroscience2019
Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Early Life Sleep Deprivation and Brain Development: Insights From Human and Animal Studies.Frontiers in neuroscience · 2022Pooled it
- Dualistic and inconsistent role of total and rapid-eye movement (REM) sleep deprivation on depressive-like behaviors in rats: a systematic review.Sleep and biological rhythms · 2025Review
- Ectopic expression of Slc1a2 in the prefrontal cortex of sleep-deprived male mice counteracts the glutamate/GABA-glutamine dysfunction.BMC biology · 2025Article
- Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.Archives of pharmacal research · 2025Review
- Selective REM sleep restriction in mice using a device designed for tunable somatosensory stimulation.Journal of neuroscience methods · 2024Article
- Adolescent sleep and its disruption in depression and anxiety.Frontiers in neuroscience · 2024Review
- Outdoor nighttime light exposure (light pollution) is associated with Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Sleep Deprivation-Induced Oxidative Stress in Rat Models: A Scoping Systematic Review.Antioxidants (Basel, Switzerland) · 2023Article
- Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial.Pain and therapy · 2023Article
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry.Pharmacological reports : PR · 2023Article
- Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction.Nutrients · 2023Article
- Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Frontiers in cellular neuroscience · 2023Review
- Neural consequences of chronic sleep disruption.Trends in neurosciences · 2022Review
- Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats.Frontiers in neuroscience · 2022Article
- Article
- Understanding stress: Insights from rodent models.Current research in neurobiology · 2021Review
- Sleep, brain vascular health and ageing.GeroScience · 2020Review
- Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The adverse consequences of early-life sleep deprivation on mental health are well recognized, yet many aspects remain unknown, therefore, animal studies can offer useful insights. Male Sprague-Dawley rats at postnatal day (PND) 19 were subjected to sleep deprivation (SD) for 14 days (6-8 hours/day). Control (CON) rats were gently handled. Behavior tests were done on PND33, PND60 and PND90. SD rats exhibited anxiety-like behavior at PND33 and PND60, when compared to CON rats. Depression-like behavior was observed at PND90. Evaluation of oxidative stress and inflammatory markers revealed interesting results. Plasma 8-isoprostane and antioxidant defense enzymes; hemeoxygenase-1, superoxide dismutase, glutathione peroxidase in the prefrontal cortex (PFC), were upregulated in SD rats at PND33 but not at PND90. PFC interleukin-6 protein expression was elevated at PND33 and PND90. PFC mitogen activated protein kinase phosphatase-1 (MKP-1) and p-38 protein expression were upregulated at PND90. PFC expression of glutamate receptor subunits, post synaptic density protein (PSD-95), calcium/calmodulin-dependent protein kinase (CaMKII), and extracellular signal-regulated kinase (ERK
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.