ReviewToxicology2019
Mechanisms of soft and hard electrophile toxicities.
Review in Toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Anticonvulsant activity of aza-Biginelli derivatives related to JM-II-43A and HSAB-based rationalization of their pharmacological profile.Journal of computer-aided molecular design · 2026Article
- Targeting Highly Reactive Oxygen Species (hROS) for Prodrug Activation through a Cascade Reaction with Kinetic Tunability (CReKT) to Effect Linker Cleavage.Journal of medicinal chemistry · 2026Article
- Plant-derived soft electrophiles upregulate pro-resolving oxylipins in a paraquat-inducedbioRxiv : the preprint server for biology · 2026Article
- Experimental and In Silico Studies to Unravel the Antioxidant and Antibacterial Properties of Lichen Metabolites fromAntioxidants (Basel, Switzerland) · 2025Article
- Equations for estimating binary mixture toxicity: Methyl-2-chloroacetoacetate-containing combinations.Toxicology reports · 2025Article
- Article
- Esterified Indole-3-propionic Acid: A Novel Inhibitor against Cholinesterase Identified through Experimental and Computational Approaches.ACS omega · 2025Article
- Toxicological evaluation of volatile organic compounds emitted from scented candles:Frontiers in public health · 2025Article
- Thiol-Based Redox Molecules: Potential Antidotes for Acrylamide Toxicity.Antioxidants (Basel, Switzerland) · 2024Article
- Solid-Phase Reactivity-Directed Extraction (SPREx): An Alternative Approach for Simultaneous Extraction, Identification, and Prioritization of Toxic Electrophiles Produced in Water Treatment Applications.ACS environmental Au · 2024Article
- Cyprocide selectively kills nematodes via cytochrome P450 bioactivation.Nature communications · 2024Article
- Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes.RSC medicinal chemistry · 2024Article
- Bioorthogonal photocatalytic proximity labeling in primary living samples.Nature communications · 2024Article
- Equations for estimating binary mixture toxicity: 3-methyl-2-butanone with a series of electrophiles.PloS one · 2024Article
- Unveiling heterocyclic aromatic amines (HAAs) in thermally processed meat products: Formation, toxicity, and strategies for reduction - A comprehensive review.Food chemistry: X · 2023Review
- Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response.Chemical research in toxicology · 2023Article
- Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library.Computational toxicology (Amsterdam, Netherlands) · 2023Article
- Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking andHeliyon · 2022Article
- Imidazole and nitroimidazole derivatives as NADH-fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking.Journal of computational chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Electron-deficient chemicals (electrophiles) react with compounds that have one or more unshared valence electron pairs (nucleophiles). The resulting covalent reactions between electrophiles and nucleophiles (e.g., Michael addition, S
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.