Evidence map›Paper›PMID 30826364›Full record

ArticleThe Journal of allergy and clinical immunology2019

T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients.

Mohammed F Alosaimi, Hiba Shendi, Abdallah Beano, Kelsey Stafstrom, Rabab El Hawary, Safa Meshaal, Nermeen Galal, Sung-Yun Pai, Aisha El-Marsafy, Raif S Geha and 1 more

Abstract readCase ReportsLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Heterozygous variants in DOCK2 leading to susceptibility to viral illnesses.The Journal of allergy and clinical immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Long COVID as a Tauopathy: Of "Brain Fog" and "Fusogen Storms".International journal of molecular sciences · 2023
    Review
  6. Review
  7. Insights from DOCK2 in cell function and pathophysiology.Frontiers in molecular biosciences · 2022
    Review
  8. First patient in the Iranian Registry with novel DOCK2 gene mutation, presenting with skeletal tuberculosis, and review of literature.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammed F AlosaimiDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass; Department of Pediatrics, Allergy/Immunology Division, King Saud University, Riyadh, Saudi Arabia.
Hiba ShendiDepartment of Pediatrics, Allergy/Immunology Division, Tawam Hospital and College of Medicine and Health Sciences, Al Ain, United Arab Emirates.
Abdallah BeanoDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Kelsey StafstromDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Rabab El HawaryClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Safa MeshaalClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Nermeen GalalPediatrics Department, Cairo University, Cairo, Egypt.
Sung-Yun PaiDivision of Hematology-Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Mass.
Aisha El-MarsafyPediatrics Department, Cairo University, Cairo, Egypt.
Raif S GehaDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
Janet ChouDivision of Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Mass. Electronic address: Janet.Chou@childrens.harvard.edu.

Funding

Mechanisms of a Novel Combined Immunodeficiency Caused by a Homozygous Mutation in COPG1R01AI139633 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2018 to 2022
$3.1M
Novel mechanisms of T cell costimulation: the role of LRRC8A in T cell activationK08AI116979 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHOU, JANET · 2015 to 2019
$934k
NIAID NIH HHS K08 AI116979NIAID NIH HHS R01 AI139633
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

FemaleGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHumansImmunologic Deficiency SyndromesInfantMaleMitochondriaMutationT-LymphocytesDOCK2 protein, humanGTPase-Activating ProteinsGuanine Nucleotide Exchange Factors

Identifiers

PMID30826364
PMCPMC6612298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.