ArticleVision research2019
Evaluating seasonal changes of cone photoreceptor structure in the 13-lined ground squirrel.
Article in Vision research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- Prevalence and Clinical Characteristics of Dark Without Pressure Retinal Changes in a Chinese Hospital-Based Population.Ophthalmology and therapy · 2025Article
- Seasonal Variation in ATP-Induced Retinal Damage in the Cone-Dominant 13-Lined Ground Squirrel.Translational vision science & technology · 2024Article
- Chemically induced cone degeneration in the 13-lined ground squirrel.Visual neuroscience · 2024Article
- Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel.Stem cell reports · 2024Article
- Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivity to light.Science advances · 2022Article
- Cone photoreceptor reflectance variation in the northern tree shrew and thirteen-lined ground squirrel.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Transcriptomic analysis of the mouse retina after acute and chronic normobaric and hypobaric hypoxia.Scientific reports · 2021Article
- Optical Coherence Tomography Angiography in the Thirteen-Lined Ground Squirrel.Translational vision science & technology · 2021Article
- Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy.Biomedical optics express · 2021Article
- Measuring the spatial distribution of multiply scattered light using a de-scanned image sensor for examining retinal structure contrast.Optics express · 2021Article
- Daily mitochondrial dynamics in cone photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Optimized Signal Flow through Photoreceptors Supports the High-Acuity Vision of Primates.Neuron · 2020Article
- Ground squirrel - A cool model for a bright vision.Seminars in cell & developmental biology · 2020Review
- Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat.Investigative ophthalmology & visual science · 2020Article
- Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology.Translational vision science & technology · 2020Article
- Characterization of Retinal Structure in ATF6-Associated Achromatopsia.Investigative ophthalmology & visual science · 2019Article
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Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Cone photoreceptors of the 13-lined ground squirrel (13-LGS) undergo reversible structural changes during hibernation, including cone outer segment disc degeneration and inner segment mitochondria depletion. Here, we evaluated cone structure with adaptive optics scanning light ophthalmoscopy (AOSLO) before, during, and after hibernation. Also, intra-animal comparisons of cone structure were made at distinct physiological states (pre-hibernation, torpor, interbout euthermia, and post-hibernation) with AOSLO and transmission electron microscopy. Our results indicate that the 13-LGS cone mosaic is only transiently affected by structural remodeling during hibernation. Outer segment remodeling starts during torpid states during a period of fall transition in room temperature, with more severe structural changes during bouts of torpor in cold temperature. Cones return to euthermic-like structure during brief periods of interbout euthermia and recover normal waveguiding properties as soon as 24 h post-hibernation. Cone structure is visible with split-detector AOSLO throughout hibernation, providing evidence that intact outer segments are not necessary to visualize cones with this technique. Despite the changes to cone structure during hibernation, cone density and packing remained unchanged throughout the seasonal cycle. Pairing non-invasive imaging with ultrastructural assessment may provide insight to the biological origins of cone photoreceptor signals observed with AOSLO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.