Evidence map›Paper›PMID 30826183›Full record

ArticleNeuron2019

Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.

Amanda L Zimmerman, Eleni M Kovatsis, Riana Y Pozsgai, Aniqa Tasnim, Qiyu Zhang, David D Ginty

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  6. Sensory Feedback and the Dynamic Control of Movement.Annual review of neuroscience · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amanda L ZimmermanDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Eleni M KovatsisDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Riana Y PozsgaiDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Aniqa TasnimDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Qiyu ZhangDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
David D GintyDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: david_ginty@hms.harvard.edu.
Howard Hughes Medical Institute · USHarvard University · US

Funding

Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Howard Hughes Medical InstituteNINDS NIH HHS R35 NS097344
6 · The paper itself

Abstract

Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gain and acuity in sensory systems. Here, we define circuit mechanisms and functions of PSI of cutaneous somatosensory neuron inputs to the spinal cord. We observed that PSI can be evoked by different sensory neuron populations and mediated through at least two distinct dorsal horn circuit mechanisms. Low-threshold cutaneous afferents evoke a GABA

Indexed as

Behavior, AnimalNeural InhibitionTouchAnimalsBicucullineDiscrimination, PsychologicalGABA-A Receptor AntagonistsHyperesthesiaMiceNerve Tissue ProteinsNeurons, AfferentPresynaptic TerminalsPyridazinesReceptors, GABA-AReceptors, N-Methyl-D-AspartateSensory Receptor CellsBicucullinebicuculline methochlorideGABA-A Receptor AntagonistsgabazineGabrb3 protein, mouseGprin1 protein, mouseNerve Tissue ProteinsPyridazinesReceptors, GABA-AReceptors, N-Methyl-D-Aspartate

Identifiers

PMID30826183
PMCPMC6472967
OpenAlexW2915960644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.