ArticleNeurobiology of aging2019
Age-dependent changes in clock neuron structural plasticity and excitability are associated with a decrease in circadian output behavior and sleep.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster.Mechanisms of ageing and development · 2026Article
- Hypergravity exposure leads to persistent effects on geotaxis and activity in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes.Nature communications · 2024Article
- Sex- and strain-dependent effects of ageing on sleep and activity patterns in Drosophila.PloS one · 2024Article
- Dynamic neuronal instability generates synaptic plasticity and behavior: Insights from Drosophila sleep.Neuroscience research · 2024Review
- Circadian Regulation of the Neuroimmune Environment Across the Lifespan: From Brain Development to Aging.Journal of biological rhythms · 2023Review
- Blue light exposure-dependent improvement in robustness of circadian rest-activity rhythm in aged rats.PloS one · 2023Article
- A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.PLoS biology · 2022Article
- Article
- Circadian rhythms as modulators of brain health during development and throughout aging.Frontiers in neural circuits · 2022Review
- Age-Related Unstructured Spike Patterns and Molecular Localization inFrontiers in physiology · 2022Article
- DYRK1a Inhibitor Mediated Rescue ofFrontiers in pharmacology · 2022Article
- High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes.Nutrients · 2021Article
- Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing.Nature communications · 2021Article
- Assessing olfactory, memory, social and circadian phenotypes associated with schizophrenia in a genetic model based on Rim.Translational psychiatry · 2021Article
- The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.Neurobiology of disease · 2020Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aging has significant effects on circadian behavior across a wide variety of species, but the underlying mechanisms are poorly understood. Previous work has demonstrated the age-dependent decline in behavioral output in the model organism Drosophila. We demonstrate that this age-dependent decline in circadian output is combined with changes in daily activity of Drosophila. Aging also has a large impact on sleep behavior, significantly increasing sleep duration while reducing latency. We used electrophysiology to record from large ventral lateral neurons of the Drosophila circadian clock, finding a significant decrease in input resistance with age but no significant changes in spontaneous electrical activity or membrane potential. We propose this change contributes to observed behavioral and sleep changes in light-dark conditions. We also demonstrate a reduction in the daily plasticity of the architecture of the small ventral lateral neurons, likely underlying the reduction in circadian rhythmicity during aging. These results provide further insights into the effect of aging on circadian biology, demonstrating age-related changes in electrical activity in conjunction with the decline in behavioral outputs.
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Registered trials
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