Evidence map›Paper›PMID 30825539›Full record

ArticleJournal of biomedical informatics2019

Distributed learning from multiple EHR databases: Contextual embedding models for medical events.

Ziyi Li, Kirk Roberts, Xiaoqian Jiang, Qi Long

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Differential privacy in health research: A scoping review.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  10. Federated Learning for Healthcare Informatics.Journal of healthcare informatics research · 2021
    Article
  11. Article
  12. Patient Representation Transfer Learning from Clinical Notes based on Hierarchical Attention Network.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziyi LiEmory University, Department of Biostatistics and Bioinformatics, Atlanta, GA 30332, USA.
Kirk RobertsUniversity of Texas, Health Science Center at Houston, School of Biomedical Informatics, Houston, TX 77030, USA.
Xiaoqian JiangUniversity of Texas, Health Science Center at Houston, School of Biomedical Informatics, Houston, TX 77030, USA. Electronic address: Xiaoqian.Jiang@uth.tmc.edu.
Qi LongUniversity of Pennsylvania, Perelman School of Medicine, Department of Biostatistics, Epidemiology and Informatics, Philadelphia, PA 19104, USA. Electronic address: qlong@pennmedicine.upenn.edu.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
Decentralized differentially-private methods for dynamic data release and analysisR01GM118609 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN, OHNO-MACHADO, LUCILA · 2017 to 2020
$2.3M
Privacy-preserving methods and tools for handling missing data in distributed health data networksR01GM124111 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2017 to 2020
$2.3M
Encryption methods and software for privacy-preserving analysis of biomedical dataU01EB023685 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI TANG, HAIXU, WANG, XIAOFENG · 2016 to 2018
$1.4M
iCONCUR: informed CONsent for Clinical data and biosample Use for ResearchR01HG008802 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN, KIM, HYEON-EUI · 2015 to 2017
$1.3M
Secure and PrivAte Collaborative EnvironmentS (SPACES) for biomedical analyticsR01GM118574 · NIGMS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI VAIDYA, JAIDEEP · 2017 to 2019
$1.1M
SHARE: Statistical Health Information Release with Differential PrivacyR01GM114612 · NIGMS · EMORY UNIVERSITY · PI XIONG, LI · 2015 to 2017
$1.0M
Statistical Methods for Causal Inference in Observational StudiesR21NS091630 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2015 to 2016
$424k
Protect Privacy of Healthcare Data in the CloudR21LM012060 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2014 to 2015
$376k
NCI NIH HHS P30 CA016520NHGRI NIH HHS R01 HG008802NHLBI NIH HHS U54 HL108460NIBIB NIH HHS U01 EB023685NIGMS NIH HHS R01 GM114612NIGMS NIH HHS R01 GM118574NIGMS NIH HHS R01 GM118609NIGMS NIH HHS R01 GM124111NINDS NIH HHS R21 NS091630NLM NIH HHS R21 LM012060
6 · The paper itself

Abstract

Electronic health record (EHR) data provide promising opportunities to explore personalized treatment regimes and to make clinical predictions. Compared with regular clinical data, EHR data are known for their irregularity and complexity. In addition, analyzing EHR data involves privacy issues and sharing such data is often infeasible among multiple research sites due to regulatory and other hurdles. A recently published work uses contextual embedding models and successfully builds one predictive model for more than seventy common diagnoses. Despite of the high predictive power, the model cannot be generalized to other institutions without sharing data. In this work, a novel method is proposed to learn from multiple databases and build predictive models based on Distributed Noise Contrastive Estimation (Distributed NCE). We use differential privacy to safeguard the intermediary information sharing. The numerical study with a real dataset demonstrates that the proposed method not only can build predictive models in a distributed manner with privacy protection, but also preserve model structure well and achieve comparable prediction accuracy. The proposed methods have been implemented as a stand-alone Python library and the implementation is available on Github (https://github.com/ziyili20/DistributedLearningPredictor) with installation instructions and use-cases.

Indexed as

Computer Communication NetworksElectronic Health RecordsMachine LearningDiagnosis, Computer-AssistedHumansContextual embedding modelsDiagnoses predictionDistributed computingEHR data

Identifiers

PMID30825539
PMCPMC6533615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.