ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019
Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Parental Age and the Risk of ADHD in Offspring: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- The fertility of a sub-population of stallions is negatively affected by ambient climatic conditions, mediated through DNA damage.International journal of biometeorology · 2026Article
- A new perspective on the causal pathway between maternal mental health and neonatal adversity.Archives of women's mental health · 2025Article
- Association between infant feeding and ADHD development in childhood: a birth cohort study in Taiwan.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Familial confounding in the associations between maternal health and autism.Nature medicine · 2025Article
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- Maternal Thyroid Dysfunction During Pregnancy as an Etiologic Factor in Autism Spectrum Disorder: Challenges and Opportunities for Research.Thyroid : official journal of the American Thyroid Association · 2024Review
- Associations of parental mental disorders and age with childhood mental disorders: a population-based cohort study with four million offspring.European child & adolescent psychiatry · 2023Article
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- Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan.Molecular psychiatry · 2022Article
- The role of early-life family composition and parental socio-economic status as risk factors for obsessive-compulsive disorder in a Danish national cohort.Journal of psychiatric research · 2022Article
- Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder.JAMA network open · 2022Article
- A multifactorial model for the etiology of neuropsychiatric disorders: the role of advanced paternal age.Pediatric research · 2022Review
- Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?-A Retrospective Study.Life (Basel, Switzerland) · 2021Article
- An exploratory analysis of the relationship between paternal age at pregnancy and difficulties symptomatic of specific learning disorders among Japanese undergraduate students.Journal of rural medicine : JRM · 2021Article
- The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism.Autism research : official journal of the International Society for Autism Research · 2020Article
- Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management.Translational pediatrics · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveParental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT).
methodThe study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time.
resultsYounger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed.
conclusionThis study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
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