Evidence map›Paper›PMID 30825301›Full record

ReviewMicrobiology spectrum2019

Type VI Secretion Systems and the Gut Microbiota.

Michael J Coyne, Laurie E Comstock

Abstract readReview
In one paragraph

Review in Microbiology spectrum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 92 citations in OpenAlex.

  1. Bridging the gap:Gut microbes · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. AmicroLife · 2026
    Article
  7. Article
  8. Review
  9. A nonenzymatic effector disruptsProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. PathogenicbioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Genomic analysis ofFrontiers in microbiology · 2024
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael J CoyneDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Laurie E ComstockDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Brigham and Women's Hospital · US

Funding

Secreted antimicrobial proteins of the intestinal BacteriodalesR01AI093771 · NIAID · UNIVERSITY OF CHICAGO · PI LAURIE E COMSTOCK · 2012 to 2026
$5.1M
A new paradigm of respiration in the human gut BacteroidesR01AI132580 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI BARQUERA, BLANCA, COMSTOCK, LAURIE E · 2017 to 2020
$2.4M
Contact-Dependent Antagonism in Gut BacteroidalesR01AI120633 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI COMSTOCK, LAURIE E · 2015 to 2019
$2.1M
NIAID NIH HHS R01 AI093771NIAID NIH HHS R01 AI120633NIAID NIH HHS R01 AI132580
6 · The paper itself

Abstract

The human colonic microbiota is a dense ecosystem comprised of numerous microbes, including bacteria, phage, fungi, archaea, and protozoa, that compete for nutrients and space. Studies are beginning to reveal the antagonistic mechanisms that gut bacteria use to compete with other members of this ecosystem. In the healthy human colon, the majority of the Gram-negative bacteria are of the order

Indexed as

Type VI Secretion SystemsAntibiosisBacteriaBacterial ProteinsColonEcologyGastrointestinal MicrobiomeGastrointestinal TractHumansProteobacteriaSymbiosisBacterial ProteinsType VI Secretion Systems

Identifiers

PMID30825301
PMCPMC6404974
OpenAlexW2919361173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.