Observational studyActa paediatrica (Oslo, Norway : 1992)2019
Survival rates for surgically treated necrotising enterocolitis have improved over the last four decades.
Observational study in Acta paediatrica (Oslo, Norway : 1992), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- [Effect of intraoperative hypothermia on short-term prognosis in neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Analysis of risk factors and establishment of a predictive model for brain injury in neonates with surgical necrotizing enterocolitis: a retrospective study.BMC pediatrics · 2025Article
- Risks and benefits of probiotics for preterm neonates: threshold of comfort or fear?Pediatric research · 2025Article
- [Comparative analysis of clinical characteristics of term and preterm neonates with necrotizing enterocolitis undergoing surgery].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Impact of Enteral Nutrition on Clinical Outcomes in Very Low Birth Weight Infants in the NICU: A Single-Center Retrospective Cohort Study.Nutrients · 2025Article
- Do hematological biomarkers predict surgical necrotizing enterocolitis?Pediatric research · 2024Article
- Gut-Brain cross talk: The pathogenesis of neurodevelopmental impairment in necrotizing enterocolitis.Frontiers in pediatrics · 2023Review
- Vascular adhesion protein-1 expression is reduced in the intestines of infants with necrotizing enterocolitis: an observational research study.BMC pediatrics · 2022Observational
- Hyaluronic Acid 35 kDa Protects against a Hyperosmotic, Formula Feeding Model of Necrotizing Enterocolitis.Nutrients · 2022Article
- Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Modelling mortality within 28 days among preterm infants at a tertiary hospital in Lusaka, Zambia: a retrospective review of hospital-based records.The Pan African medical journal · 2021Article
- Clinical Characteristics of Necrotizing Enterocolitis in Preterm Patients With and Without Persistent Ductus Arteriosus and in Patients With Congenital Heart Disease.Frontiers in pediatrics · 2020Article
Corrections and comments
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2 authors.
Funding
Abstract
aimImproved survival rates for premature infants have also increased the population at risk of necrotising enterocolitis (NEC). This study evaluated the outcomes of surgically treated NEC and identified risk factors for mortality, intestinal failure (IF) and IF associated liver disease (IFALD).
methodsThis was a retrospective observational study of 131 infants with surgically treated NEC from 1976 to 2016 in a Swedish tertiary referral centre: 20 in 1976-1996, 33 in 1997-2006 and 78 in 2007-2016. Data were extracted from medical records, and the Cox regression model was used to identify risk factors.
resultsWhen the first and last periods were compared, they showed decreases in both gestational age, from 30 to 26 weeks, and mortality rates, from 45% to 29%. IF was found in 67 patients (56%), IFALD in 41 patients (34%) and short bowel syndrome (SBS) in 13 (19%). The incidence of IF was high, even in infants without SBS. Low gestational age was an independent risk factor for mortality. No risk factors were identified for IF or IFALD.
conclusionSurvival rates for NEC improved from 1976-2016, despite a decrease in gestational age. Clinicians should be particularly aware of the risk of infants without SBS developing IF.
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