ArticleBritish journal of pharmacology2019
Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- An All-Optical Approach to Probe Chloride Transport with a Bright ChlorON.bioRxiv : the preprint server for biology · 2026Article
- Lipophilic mono-guanidinesRSC advances · 2026Article
- Chlorination-Enhanced HChemistry, an Asian journal · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.Angewandte Chemie (International ed. in English) · 2025Article
- Anti-Microorganisms · 2023Review
- Small molecule anion carriers facilitate lactate transport in model liposomes and cells.iScience · 2023Article
- Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors.Chemical reviews · 2023Review
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- Hydroxychloroquine Does Not Function as a Direct Zinc Ionophore.Pharmaceutics · 2022Article
- Recent Advances in Bioactive Artificial Ionophores.Chembiochem : a European journal of chemical biology · 2021Review
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
- New Therapies to Correct the Cystic Fibrosis Basic Defect.International journal of molecular sciences · 2021Review
- Tambjamines and Prodiginines: Biocidal Activity againstPharmaceutics · 2021Article
- Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis.Journal of experimental pharmacology · 2021Review
- Correctors modify the bicarbonate permeability of F508del-CFTR.Scientific reports · 2020Article
- Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia.International journal of molecular sciences · 2020Article
- Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.Chemical science · 2019Article
- Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.British journal of pharmacology · 2019Article
- Investigating the Influence of Steric Hindrance on Selective Anion Transport.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCystic fibrosis (CF) is a lethal autosomal recessive genetic disease that originates from the defective function of the CF transmembrane conductance regulator (CFTR) protein, a cAMP-dependent anion channel involved in fluid transport across epithelium. Because small synthetic transmembrane anion transporters (anionophores) can replace the biological anion transport mechanisms, independent of genetic mutations in the CFTR, such anionophores are candidates as new potential treatments for CF. EXPERIMENTAL APPROACH: In order to assess their effects on cell physiology, we have analysed the transport properties of five anionophore compounds, three prodigiosines and two tambjamines. Chloride efflux was measured in large uni-lamellar vesicles and in HEK293 cells with chloride-sensitive electrodes. Iodide influx was evaluated in FRT cells transfected with iodide-sensitive YFP. Transport of bicarbonate was assessed by changes of pH after a NH KEY
resultsAll studied compounds are capable of transporting halides and bicarbonate across the cell membrane, with a higher transport capacity at acidic pH. Interestingly, the presence of these anionophores did not interfere with the activation of CFTR and did not modify the action of lumacaftor (a CFTR corrector) or ivacaftor (a CFTR potentiator). CONCLUSION AND IMPLICATIONS: These anionophores, at low concentrations, transported chloride and bicarbonate across cell membranes, without affecting CFTR function. They therefore provide promising starting points for the development of novel treatments for CF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.