Evidence map›Paper›PMID 30825110›Full record

ArticleDigestive diseases and sciences2019

Antifibrotic Effects of 1,25(OH)

Lingyun Ma, Masatoshi Ishigami, Takashi Honda, Shinya Yokoyama, Kenta Yamamoto, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Yoshiki Hirooka, Hidemi Goto

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Vitamin D 1,25-Dihydroxyvitamin DWorld journal of gastrointestinal oncology · 2024
    Article
  3. Article
  4. Do Interactions of Vitamin DCurrent osteoporosis reports · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lingyun MaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Masatoshi IshigamiDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. masaishi@med.nagoya-u.ac.jp.
Takashi HondaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Shinya YokoyamaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Kenta YamamotoDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Yoji IshizuDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Teiji KuzuyaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Kazuhiko HayashiDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Yoshiki HirookaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Hidemi GotoDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
Nagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH.

aimWe performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce NASH, and then investigated the effects of treatment with 1,25(OH)

methodsSeven-week-old C57BL/6J female mice were separated into five experimental groups: SHAM, OVX, and OVX + intraperitoneal (i.p.) injection of 1,25(OH)

resultsSupplementation of 1,25(OH)

conclusionSupplementation of 1,25(OH)

Indexed as

ActinsAlanine TransaminaseAnimalsAspartate AminotransferasesCalcitriolCholineCollagen Type ICollagen Type I, alpha 1 ChainDiet, High-FatFemaleGene ExpressionInterleukin-6MiceNon-alcoholic Fatty Liver DiseaseOvariectomyReceptors, CalcitriolActinsAlanine Transaminasealpha-smooth muscle actin, mouseAspartate AminotransferasesCalcitriolCholineCollagen Type ICollagen Type I, alpha 1 ChainInterleukin-6interleukin-6, mouseReceptors, CalcitriolRNA, MessengerSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseTimp1 protein, mouseTissue Inhibitor of Metalloproteinase-1Transforming Growth Factor betaTumor Necrosis Factor-alphaVdr protein, mouseVitamins1,25(OH)2D3FibrosisNonalcoholic steatohepatitisOvariectomyVitamin D receptor

Identifiers

PMID30825110
OpenAlexW2919181358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.