Evidence map›Paper›PMID 30824994›Full record

ArticleLung2019

Bronchoscopic Brushing from Central Lung Cancer-Next Generation Sequencing Results are Reliable.

Lars Hagmeyer, Jana Fassunke, Marianne Engels, Marcel Treml, Simon Herkenrath, Sandhya Matthes, Reinhard Büttner, Winfried Randerath

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lars HagmeyerHospital Bethanien Solingen, Institute of Pneumology, University of Cologne, Solingen, Germany. lars.hagmeyer@klinik-bethanien.de.ORCID 0000-0003-4285-1244
Jana FassunkeInstitute for Pathology, University Hospital Cologne, Cologne, Germany.
Marianne EngelsInstitute for Pathology, University Hospital Cologne, Cologne, Germany.
Marcel TremlHospital Bethanien Solingen, Institute of Pneumology, University of Cologne, Solingen, Germany.
Simon HerkenrathHospital Bethanien Solingen, Institute of Pneumology, University of Cologne, Solingen, Germany.
Sandhya MatthesHospital Bethanien Solingen, Institute of Pneumology, University of Cologne, Solingen, Germany.
Reinhard BüttnerInstitute for Pathology, University Hospital Cologne, Cologne, Germany.
Winfried RanderathHospital Bethanien Solingen, Institute of Pneumology, University of Cologne, Solingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of bronchoscopic brushing for tumor detection and molecular testing in central lung cancer is unclear. In this study, 50 consecutive subjects with suspected central lung cancer underwent bronchoscopic brushing (31 males, median age 70, 5 never smokers). Histological results were: NSCLC/SCLC/low-grade-NET/granulation tissue in 36/8/2/4 cases. Next generation sequencing (NGS) was feasible in 62% of tumor-positive brush smear samples. In 78% of these cases, NGS displayed identical results compared to histology samples, in 22% NGS from brush smears detected specific mutations, whereas DNA quality from forceps biopsy was insufficient for NGS analysis. Sensitivity, specificity, positive predictive value, negative predictive value of brush smear analysis were 66% (95% confidence interval 50-79), 100% (40-100), 100% (85-100), and 21% (7-46). For the combined analysis of brush smear, brush tip washing and sheath tube content sensitivity was slightly elevated at 69% (53-81). In central lung cancer, bronchoscopic brushing detects tumor cells in about two-third of cases and allows a decision for or against targeted therapy in the majority of tumor-positive cases on the basis of NGS analysis.

Indexed as

AgedBiopsyBronchoscopyCarcinoma, Non-Small-Cell LungClinical Decision-MakingFemaleGranulation TissueHigh-Throughput Nucleotide SequencingHumansLung NeoplasmsMaleMiddle AgedMolecular Targeted TherapyNeuroendocrine TumorsRetrospective StudiesSensitivity and SpecificityBrushing cytologyCarcinomaDiagnostic bronchoscopyMolecular genetic testingTumor detection

Identifiers

PMID30824994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.