Evidence map›Paper›PMID 30824959›Full record

SynthesisWorld journal of surgery2019

The Effect of Perioperative Iron Therapy in Acute Major Non-cardiac Surgery on Allogenic Blood Transfusion and Postoperative Haemoglobin Levels: A Systematic Review and Meta-analysis.

Anders Schack, Adam A Berkfors, Sarah Ekeloef, Ismail Gögenur, Jakob Burcharth

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06948864 (Evaluation of the Role of Preoperative Intravenous Iron in Patients Undergoing Surgery), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06948864 completednot on this mapstarted 2020, after this paper: background citation

Evaluation of the Role of Preoperative Intravenous Iron in Patients Undergoing Surgery

TypeobservationalSponsorHospital Universitario Infanta CristinaRan2020 to 2024Enrolled152ConditionsAnemia, Anemia (Iron-Loading), Perioperative Bleeding, Infection PreventionArmsFerric Carboxymaltose (FCM)
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Blood transfusion in major emergency abdominal surgery.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Observational
  9. Review
  10. Article
  11. Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anders SchackCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital & University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark. aesc@regionsjaelland.dk.ORCID 0000-0002-9280-0384
Adam A BerkforsCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital & University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark.
Sarah EkeloefCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital & University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark.
Ismail GögenurCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital & University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark.
Jakob BurcharthCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital & University of Copenhagen, Lykkebaekvej 1, 4600, Koege, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative anaemia in relation to surgery is associated with adverse clinical outcomes. In an elective surgical setting, it is possible to optimize patients prior to surgery, often by iron supplementation with correction of anaemia. Possibilities for optimization prior to and during acute surgical procedures are limited. This review investigates whether iron treatment initiated perioperatively improves outcomes in patients undergoing major acute non-cardiac surgery.

methodThis systematic review was performed using PubMed, EMBASE (Ovid) and Scopus to identify current evidence on iron supplementation in acute surgery. Primary outcomes were allogenic blood transfusion (ABT) rate and changes in haemoglobin. Secondary outcomes were postoperative mortality, length of stay (LOS), and postoperative complications. Iron was administered at latest within 24 h after end of surgery.

resultsOf the 5413 studies screened, four randomized controlled trials and nine observational cohort studies were included. Ten studies included patients with hip fractures. A meta-analysis of seven studies showed a risk reduction of transfusion (OR = 0.35 CI 95% (0.20-0.63), p = 0.0004, I

conclusionsThis review examined perioperative iron therapy in acute major non-cardiac surgery. IV iron showed a lower 30-day mortality, a reduction in postoperative infections and a reduction in ABT largely due to the observational studies. The review primarily consisted of small observational studies and does not have the power to formally recommend this practice.

Indexed as

Blood TransfusionPerioperative CareAnemiaElective Surgical ProceduresHemoglobinsHip FracturesHumansIronLength of StayMortalityObservational Studies as TopicPostoperative ComplicationsPostoperative PeriodRandomized Controlled Trials as TopicHemoglobinsIron

Identifiers

PMID30824959
OpenAlexW2918465339

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.