ArticleAge and ageing2019
Association of blood pressure with clinical outcomes in older adults with chronic kidney disease.
Article in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Age-stratified association between blood pressure and clinical outcomes in maintenance hemodialysis patients.International urology and nephrology · 2026Article
- Nocturnal Stage 1 Hypertension Defined by 2025 Guidelines in Adults With Chronic Kidney Disease.JAMA network open · 2026Article
- Blood pressure and adverse cardiovascular outcomes in older people with type 2 diabetes and chronic kidney disease: Findings based on the Clinical Practice Research Datalink databases in England.Diabetes, obesity & metabolism · 2026Article
- Estimating the prevalence of chronic kidney disease in the older population using health screening data in Japan.Clinical and experimental nephrology · 2025Article
- Management of Elderly Patients with Chronic Kidney Disease.Yonsei medical journal · 2025Review
- Management of hypertension in chronic kidney disease: current perspectives and therapeutic strategies.Frontiers in medicine · 2025Review
- Relationship between changes in late-life blood pressure and the risk of frailty and mortality among older population in China: a cohort study based on CLHLS.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Ageing meets kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Blood Pressure Control in Elderly Chronic Kidney Disease Patients.Electrolyte & blood pressure : E & BP · 2022Review
- Ageing meets kidney disease.Clinical kidney journal · 2022Article
- Predictive Effect of Renal Function on Clinical Outcomes in Older Adults With Acute Myocardial Infarction: Results From an Observational Cohort Study in China.Frontiers in cardiovascular medicine · 2021Article
- Article
- Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality.Age and ageing · 2020Observational
- Risk Factors for All-Cause and Cause-Specific Mortality in Patients with Chronic Kidney Disease: Age-Specific Associations and Attributable Burden.Kidney diseases (Basel, Switzerland)Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundin chronic kidney disease (CKD), hypertension is associated with poor outcomes at ages <70 years. At older ages, this association is unclear. We tested 10-year mortality and cardiovascular outcomes by clinical systolic blood pressure (SBP) in older CKD Stages 3 and 4 patients without diabetes or proteinuria.
methodsretrospective cohort in population representative primary care electronic medical records linked to hospital data from the UK. CKD staged by CKD-EPI equation (≥2 creatinine measurements ≥90 days apart). SBPs were 3-year medians before baseline, with mean follow-up 5.7 years. Cox competing models accounted for mortality.
resultsabout 158,713 subjects with CKD3 and 6,611 with CKD4 met inclusion criteria. Mortality increased with increasing CKD stage in all subjects aged >60. In the 70 plus group with SBPs 140-169 mmHg, there was no increase in mortality, versus SBP 130-139. Similarly, SBPs 140-169 mmHg were not associated with increased incident heart failure, stroke or myocardial infarctions. SBPs <120 mmHg were associated with increased mortality and cardiovascular risk. At ages 60-69, there was increased mortality at SBP <120 and SBP >150 mmHg.Results were little altered after excluding those with declining SBPs during 5 years before baseline, or for longer-term outcomes (5-10 years after baseline).
conclusionsin older primary care patients, CKD3 or 4 was the dominant outcome predictor. SBP 140-169 mmHg having little additional predictive value, <120 mmHg was associated with increased mortality. Prospective studies of representative older adults with CKD are required to establish optimum BP targets.
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