Evidence map›Paper›PMID 30824727›Full record

Trial reportScientific reports2019

Prognostic Value of Preoperative Systemic Immune-Inflammation Index in Patients with Cervical Cancer.

Huaping Huang, Qin Liu, Lixia Zhu, Yan Zhang, Xiaojuan Lu, Yawei Wu, Li Liu

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huaping HuangDepartment of obstetrics, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Qin LiuDepartment of Gynecology, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Lixia ZhuDepartment of Gynecology, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Yan ZhangDepartment of Gynecology, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Xiaojuan LuDepartment of Gynecology, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Yawei WuDepartment of Gynecology, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China.
Li LiuDepartment of obstetrics, The First People's Hospital of Kunshan, Jiangsu University, No. 91 West Qianjin Road, Suzhou, 215300, China. ksdyliuli@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The systemic immune-inflammation index (SII) based on peripheral lymphocyte, neutrophil and platelet counts has been considered a good index that reflects the local immune response and systemic inflammation. However, the use of the SII has not been reported in cervical cancer. In this study, Kaplan-Meier survival analysis showed that a high SII was associated with poor prognosis in cervical cancer patients in the primary and validation cohorts. A higher SII had a significant correlation with larger tumours but had no correlation with other clinicopathological parameters. Among all systemic immune indexes, the SII is the only independent prognostic factor for cervical cancer patients. Compared with the area under the curve for the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR), the area for the SII was larger at 3 and 5 years. In addition, the SII still retains it prognostic values across all FIGO stages. The SII can independently predict the overall survival of patients with cervical cancer receiving radical resection and is thus superior to existing systemic inflammatory indexes. The prognostic nomogram based on the SII is a reliable model for predicting the postoperative survival of patients with cervical cancer.

Indexed as

Models, ImmunologicalAdultAgedAged, 80 and overBlood Cell CountDisease-Free SurvivalFemaleFollow-Up StudiesHumansInflammationMiddle AgedRetrospective StudiesSurvival RateUterine Cervical Neoplasms

Identifiers

PMID30824727
PMCPMC6397230

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.