ArticleScientific reports2019
Genetic and Phytochemical Characterization of Lettuce Flavonoid Biosynthesis Mutants.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Increasing Bioactive Compound Production in Lettuce by Application ofBiomolecules · 2026Article
- CRISPR/Cas9-mediated knockout ofFrontiers in genome editing · 2026Article
- Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling.Nature communications · 2025Article
- Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population.Genome biology · 2025Article
- Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce (Molecules (Basel, Switzerland) · 2024Article
- Phytochemical and Agronomic Characterization of High-Flavonoid Lettuce Lines Grown under Field Conditions.Plants (Basel, Switzerland) · 2023Article
- LettuceGDB: The community database for lettuce genetics and omics.Plant communications · 2023Article
- The reported colour formation mechanism in pitaya fruit through co-accumulation of anthocyanins and betalains is inconsistent and fails to establish the co-accumulation.BMC genomics · 2022Article
- Prohydrojasmon Promotes the Accumulation of Phenolic Compounds in Red Leaf Lettuce.Plants (Basel, Switzerland) · 2021Article
- Isolating an active and inactive CACTA transposon from lettuce color mutants and characterizing their family.Plant physiology · 2021Article
- The Sorghum (Frontiers in plant science · 2021Article
- Genetic variation and relationship among content of vitamins, pigments, and sugars in baby leaf lettuce.Food science & nutrition · 2019Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
We previously developed red lettuce (Lactuca sativa L.) cultivars with high flavonoid and phenolic acid content and demonstrated their anti-diabetic effect. Here we report on developing three fertile and true-breeding lettuce lines enriched with flavonoids with reported beneficial health effects. These lines were identified in a segregating population of EMS-mutagenized red lettuce and characterized biochemically and genetically. Change in red coloration was used as a visual indicator of a mutation in a flavonoid pathway gene, leading to accumulation of flavonoid precursors of red anthocyanins. Pink-green kaempferol overproducing kfoA and kfoB mutants accumulated kaempferol to 0.6-1% of their dry weight, higher than in any vegetable reported. The yellow-green naringenin chalcone overproducing mutant (nco) accumulated naringenin chalcone, not previously reported in lettuce, to 1% dry weight, a level only observed in tomato peel. Kfo plants carried a mutation in the FLAVONOID-3' HYDROXYLASE (F3'H) gene, nco in CHALCONE ISOMERASE (CHI). This work demonstrates how non-GMO approaches can transform a common crop plant into a functional food with possible health benefits.
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