Evidence map›Paper›PMID 30824698›Full record

ArticleNature communications2019

Programming chain-growth copolymerization of DNA hairpin tiles for in-vitro hierarchical supramolecular organization.

Honglu Zhang, Yu Wang, Huan Zhang, Xiaoguo Liu, Antony Lee, Qiuling Huang, Fei Wang, Jie Chao, Huajie Liu, Jiang Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

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  5. Stacking Interactions and Flexibility of Human Telomeric Multimers.Journal of the American Chemical Society · 2023
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  9. Molecular Visualization of Early-Stage Acute Kidney Injury with a DNA Framework Nanodevice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  10. Article
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  12. Article
  13. DNA-Mediated Step-Growth Polymerization of Bottlebrush Macromonomers.Journal of the American Chemical Society · 2020
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Honglu Zhang *Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Yu Wang *State Key Laboratory of Physical Chemistry of Solid Surfaces and College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China.
Huan Zhang *Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Xiaoguo Liu *School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240, Shanghai, China.ORCID http://orcid.org/0000-0002-7834-399X
Antony LeeDepartment of Chemistry, Institute for Quantitative Biosciences (QB3), Department of Physics, Department of Molecular and Cell Biology, Kavli Energy Nanosciences Institute at Berkeley, Howard Hughes Medical Institute, University of California, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0003-2193-5369
Qiuling HuangDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Fei WangSchool of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240, Shanghai, China.
Jie ChaoKey Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing, 210023, China.
Huajie LiuDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Jiang LiDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Jiye ShiDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.ORCID http://orcid.org/0000-0002-9628-8680
Xiaolei ZuoSchool of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240, Shanghai, China.
Lihua WangDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China.
Lianhui WangKey Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications (NUPT), Nanjing, 210023, China.ORCID http://orcid.org/0000-0001-9030-9172
Xiaoyu CaoState Key Laboratory of Physical Chemistry of Solid Surfaces and College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China.
Carlos BustamanteDepartment of Chemistry, Institute for Quantitative Biosciences (QB3), Department of Physics, Department of Molecular and Cell Biology, Kavli Energy Nanosciences Institute at Berkeley, Howard Hughes Medical Institute, University of California, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-2970-0073
Zhongqun TianState Key Laboratory of Physical Chemistry of Solid Surfaces and College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China. zqtian@xmu.edu.cn.ORCID http://orcid.org/0000-0002-9775-8189
Chunhai FanDivision of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800, Shanghai, China. fanchunhai@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-7171-7338
Chinese Academy of Sciences · CNHoward Hughes Medical Institute · USShanghai Jiao Tong University · CNXiamen University · CNNanjing University of Posts and Telecommunications · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formation of biological filaments via intracellular supramolecular polymerization of proteins or protein/nucleic acid complexes is under programmable and spatiotemporal control to maintain cellular and genomic integrity. Here we devise a bioinspired, catassembly-like isothermal chain-growth approach to copolymerize DNA hairpin tiles (DHTs) into nanofilaments with desirable composition, chain length and function. By designing metastable DNA hairpins with shape-defining intramolecular hydrogen bonds, we generate two types of DHT monomers for copolymerization with high cooperativity and low dispersity indexes. Quantitative single-molecule dissection methods reveal that catalytic opening of a DHT motif harbouring a toehold triggers successive branch migration, which autonomously propagates to form copolymers with alternate tile units. We find that these shape-defined supramolecular nanostructures become substrates for efficient endocytosis by living mammalian cells in a stiffness-dependent manner. Hence, this catassembly-like in-vitro reconstruction approach provides clues for understanding structure-function relationship of biological filaments under physiological and pathological conditions.

Indexed as

PolymerizationA549 CellsBase SequenceCatalytic DomainDNADNA, Single-StrandedEndocytosisHumansHydrogen BondingModels, GeneticNanostructuresNucleic Acid ConformationNucleic Acid HybridizationDNADNA, Single-Stranded

Identifiers

PMID30824698
PMCPMC6397255
OpenAlexW2915951238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.