ArticleThe Journal of biological chemistry2019
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation.Nature communications · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- 1,2,3,4-Dithiadiazole Derivative 3-(4-Nitrophenyl)-5-Phenyl-3H-1,2,3,4-Dithiadiazole-2-Oxide Affects Both STIM1- and STIM2-Dependent Store-Operated Calcium Channels.Bulletin of experimental biology and medicine · 2025Article
- Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway.Science signaling · 2025Article
- Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via CaNature communications · 2025Article
- MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development.PLoS biology · 2024Article
- New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment.Cell & bioscience · 2024Review
- Article
- A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023Article
- Too much of a good thing: The case of SOCE in cellular apoptosis.Cell calcium · 2023Review
- A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.eLife · 2023Article
- Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation.Cancers · 2022Article
- Screening of Specific and Common Pathways in Breast Cancer Cell Lines MCF-7 and MDA-MB-231 Treated with Chlorophyllides Composites.Molecules (Basel, Switzerland) · 2022Article
- TRPC3 channel gating by lipids requires localization at the ER/PM junctions defined by STIM1.The Journal of cell biology · 2022Article
- Functional communication between IPProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF.The Journal of cell biology · 2021Article
- Omnitemporal choreographies of all five STIM/Orai and IPCell reports · 2021Article
- Three-Dimensional Model of Sub-Plasmalemmal CaFrontiers in immunology · 2021Article
- Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.Cell calcium · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Scott M EmrichFrom the Departments of Cellular and Molecular Physiology and.
Ryan E YoastFrom the Departments of Cellular and Molecular Physiology and.
Ping XinFrom the Departments of Cellular and Molecular Physiology and.
Xuexin ZhangFrom the Departments of Cellular and Molecular Physiology and.
Trayambak PathakFrom the Departments of Cellular and Molecular Physiology and.
Robert NwokonkoFrom the Departments of Cellular and Molecular Physiology and.ORCID 0000-0002-0793-7379
Maxime F GueguinouFrom the Departments of Cellular and Molecular Physiology and.
Krishna P Subedithe Secretory Physiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, and.
Yandong ZhouFrom the Departments of Cellular and Molecular Physiology and.
Indu S Ambudkarthe Secretory Physiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, and.
Nadine HempelPharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.
Khaled Machacathe Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.
Donald L GillFrom the Departments of Cellular and Molecular Physiology and.
Mohamed TrebakFrom the Departments of Cellular and Molecular Physiology and mtrebak@psu.edu.ORCID 0000-0001-6759-864X
Pennsylvania State University · USNational Institutes of Health · USWeill Cornell Medical College in Qatar · QA
Funding
Molecular Mechanisms Regulating Calcium Flux In Salivary GlandsZIADE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 2009 to 2025
$42.5MReceptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MCalcium Signaling Roles of STIM1 and STIM2 in Smooth MuscleR01GM109279 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2014 to 2017
$1.6MLeukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5MControl of Calcium Entry Signals in B CellsR01GM120783 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2016 to 2018
$1.3MGenes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471kNHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIA NIH HHS R21 AG050072NIGMS NIH HHS R01 GM109279NIGMS NIH HHS R01 GM120783NIGMS NIH HHS R35 GM131916
Abstract
Store-operated Ca
Indexed as
Calcium SignalingBoron CompoundsCalciumEndoplasmic ReticulumGene Knockdown TechniquesHCT116 CellsHEK293 CellsHumansNeoplasm ProteinsProtein DomainsProtein IsoformsStromal Interaction Molecule 1Stromal Interaction Molecule 22-aminoethoxydiphenyl borateBoron CompoundsCalciumNeoplasm ProteinsProtein IsoformsSTIM1 protein, humanSTIM2 protein, humanStromal Interaction Molecule 1Stromal Interaction Molecule 2calcium channelcalcium imagingcalcium intracellular releasecalcium release-activated calcium channel protein 1 (ORAI1)Calcium signalingcalcium transportcation channelIon sensorSOCESTIM2stromal interaction molecule 1 (STIM1)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.