ArticleBritish medical journal (Clinical research ed.)1986
Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A.
Article in British medical journal (Clinical research ed.), 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Immunosuppression for adult steroid-dependent or frequently relapsing nephrotic syndrome: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Immunosuppressive treatment for focal segmental glomerulosclerosis in adults.The Cochrane database of systematic reviews · 2008Pooled it
- Effect of cyclosporine A on circulating immune complexes in IgA nephropathy.International urology and nephrology · 1991Trial
- The use of cyclosporin A in adult nephrotic syndrome: nine cases and literature review.Irish journal of medical science · 1990Trial
- Cyclosporin treatment of IgA nephropathy: a short term controlled trial.British medical journal (Clinical research ed.) · 1987Trial
- [Comparison of therapeutic effects of prednisone combined with mycophenolate mofetil versus cyclosporin A in children with steroid-resistant nephrotic syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- History of Nephrotic Syndrome and Evolution of its Treatment.Frontiers in pediatrics · 2016Review
- Impact of cyclosporin on podocyte ZO-1 expression in puromycin aminonucleoside nephrosis rats.Yonsei medical journal · 2005Article
- Cyclosporin A in refractory idiopathic nephrotic syndrome: 5 years clinical experience.Postgraduate medical journal · 1994Article
- Long-term cyclosporin A treatment of minimal-change nephrotic syndrome of childhood.Pediatric nephrology (Berlin, Germany) · 1994Article
- Acute leucoencephalopathy during cyclosporin A therapy in a patient with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 1994Review
- Review
- The effect of cyclosporin A on rabbit nephrotoxic glomerulonephritis.International journal of experimental pathology · 1993Article
- Management of nephrotic syndrome in childhood.Drugs · 1991Review
- Serum interleukin-2 levels in a patient with focal segmental glomerulosclerosis. Relationship to clinical course and cyclosporin A therapy.Pediatric nephrology (Berlin, Germany) · 1990Article
- Immunosuppressive therapy in the nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 1989Review
- Cyclosporin A treatment in children with minimal change nephrotic syndrome and focal segmental glomerulosclerosis.Klinische Wochenschrift · 1988Article
- Cyclosporin in the treatment of idiopathic nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 1987Article
- Cyclosporin A in steroid-sensitive nephrotic syndrome with frequent relapses.Postgraduate medical journal · 1987Article
- The treatment of immune glomerular disease.Springer seminars in immunopathology · 1987Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrotic syndrome in minimal change lipoid nephrosis and focal segmental glomerulosclerosis may be due to alteration of glomerular anionic sites by a lymphokine. Six adults with nephrotic syndrome who were resistant to treatment with corticosteroids and immunosuppressants were treated with cyclosporin A. In three patients with minimal change lipoid nephrosis who had been nephrotic for 3.5 to 23 years proteinuria resolved within 12 to 42 days. Subsequently, these patients became dependent on cyclosporin A. In three patients with focal segmental glomerulosclerosis who had been nephrotic for four to six years mean (SD) 24 hour urinary protein decreased from 14.7 (8.4) g to 3.6 (0.6) g within 20 to 25 days, serum albumin concentration rose, and oedema subsided. One patient died of myocardial infarction when still in partial remission after 11 weeks' treatment. Two patients remained proteinuric despite continuing treatment with cyclosporin A, but control of sodium balance was easy and serum albumin concentrations remained higher than without cyclosporin A. In all patients renal function improved during treatment. These preliminary results show that cyclosporin A may be effective in the treatment of patients with nephrotic syndrome that resists every other form of treatment and especially in the treatment of those with minimal change lipoid nephrosis. The results are in keeping with a T lymphocyte mediated mechanism of minimal change lipoid nephrosis and focal segmental glomerulosclerosis, but they also suggest that minimal change lipoid nephrosis and focal segmental glomerulosclerosis are separate entities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.