Evidence map›Paper›PMID 30823919›Full record

ArticleJournal of nanobiotechnology2019

Establishment of perpendicular protrusion of type I collagen on TiO

Toshiki Nojiri, Chia-Yu Chen, David M Kim, John Da Silva, Cliff Lee, Masahiko Maeno, Arthur A McClelland, Bryan Tse, Shigemi Ishikawa-Nagai, Wataru Hatakeyama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Toshiki NojiriDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Chia-Yu ChenDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
David M KimDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
John Da SilvaDepartment of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Cliff LeeDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Masahiko MaenoDepartment of Adhesive Dentistry, The Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, Japan.
Arthur A McClellandCenter for Nanoscale Systems, Harvard University, 11 Oxford St, Cambridge, MA, USA.
Bryan TseDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Shigemi Ishikawa-NagaiDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Wataru HatakeyamaDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.
Hisatomo KondoDepartment of Prosthodontics and Oral Implantology, School of Dental Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, Japan.
Masazumi NagaiDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA. masazumi_nagai@hms.harvard.edu.
Harvard University · USIwate Medical University · JPNippon Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural teeth are supported by connective tissue collagen fibers that insert perpendicularly in the tooth cementum. Perpendicular insertion plays an important role in the maintenance of the junction between the oral epithelium and the periodontal connective tissue. Most titanium dental implant surfaces have no micro or macro structure to support perpendicularly oriented collagen attachment. Without this tight biologic seal to resist bacterial invasion and epithelial downgrowth, progressive bone loss in peri-implantitis is seen around dental implants. The purpose of this study was to establish the perpendicularly oriented collagen attachment to titanium oxide nanotube (TNT), and to assess its binding stability. TNT was prepared on the titanium-surface by anodization. Scanning electron microscopy (SEM) showed a regularly aligned TNT with an average 67 nm-diameter when anodized at 30 V for 3 h. Subsequently, collagen type I (CoI) was electrophoretically fused to anodic TNT in native polyacrylamide gel system where negatively charged CoI-C term was perpendicularly navigated to TNT. SEM and atomic force microscopy (AFM) were used to analyze CoI on the TiO

Indexed as

Dental ImplantsBiocompatible MaterialsCell AdhesionCollagen Type IConnective TissueElectrochemical TechniquesEpithelial CellsHumansNanotubesParticle SizeSurface PropertiesTitaniumBiocompatible MaterialsCollagen Type IDental ImplantsTitaniumtitanium dioxideCollagenImplant surfaceNanotubesPerpendicular orientationTitanium

Identifiers

PMID30823919
PMCPMC6396481
OpenAlexW2929680043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.