ArticleBMC endocrine disorders2019
Incidence and determinants of diabetes-related lower limb amputations in Ghana, 2010-2015- a retrospective cohort study.
Article in BMC endocrine disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Risk factors for diabetic foot complications in type 2 diabetes-A systematic review.Endocrinology, diabetes & metabolism · 2021Pooled it
- Living with type 2 diabetes: stress and daily life challenges among adults in the Ashanti Region, Ghana.BMC public health · 2026Article
- Clinical Characteristics and Outcomes of Toe Amputation Among Sudanese Diabetic Patients in Jabir Abu-Eliz Diabetic Centre at Khartoum, 2021: A Cross Sectional Study.Health science reports · 2026Article
- Evaluation of a diabetes decentralization program in rural Madagascar using the RE-AIM framework.PLOS global public health · 2026Article
- Investigating the role of perceived autonomy support in moderating the association between diabetes stigma and psychological and diabetes self-management outcomes among adults with type 2 diabetes in Ghana.PLOS global public health · 2026Article
- Diabetes-Associated Major Limb Amputation in Solomon Islands: A National, 5-Year Retrospective Study.World journal of surgery · 2025Article
- Effect of a home-based physical activity program on metabolic syndrome in Ghanaian adults with type 2 diabetes: Protocol for a feasibility randomized controlled trial.Nursing open · 2024Article
- Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis.Frontiers in endocrinology · 2024Article
- The epidemiological and economic burden of diabetes in Ghana: A scoping review to inform health technology assessment.PLOS global public health · 2024Article
- Knowledge of physical activity, physical activity level and waist-to-hip ratio in adults with diabetes in a Ghanaian municipality.Ghana medical journal · 2023Article
- Prevalence and determinants of lower extremity amputations among type I and type II diabetic patients: A multicenter-based study.International wound journal · 2023Article
- Lower extremity amputations (LEAs) in a tertiary hospital in Togo: a retrospective analysis of clinical, biological, radiological, and therapeutic aspects.Journal of orthopaedic surgery and research · 2023Article
- Diabetic foot complications-lessons learned from real-world data derived from a specialized Austrian hospital.Wiener klinische Wochenschrift · 2022Article
- Article
- Photobiomodulation at 830 nm Stimulates Migration, Survival and Proliferation of Fibroblast Cells.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Risk factors for diabetic foot complications among patients with type 2 diabetes in Austria-A registry-based retrospective cohort study.Endocrinology, diabetes & metabolism · 2021Article
- The Role of Finding Out in Type 2 Diabetes Management among West-African Immigrants Living in the UK.International journal of environmental research and public health · 2021Article
- Clinical profiles of diabetic foot ulcer patients undergoing major limb amputation at a tertiary care center in North-eastern Tanzania.BMC surgery · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes-related lower limb amputations (LLA) are associated with significant morbidity and mortality. Although the incidence has decreased over the past two decades in most High-Income Countries, the situation in Low-Middle Income Countries (LMIC), especially those in sub-Saharan Africa (SSA) is not clear. We have determined the incidence and determinants of diabetes-related LLA in Ghana.
methodsThis was a tertiary-care-based retrospective cohort study involving patients enrolled in the diabetes clinic of Komfo Anokye Teaching Hospital, Ghana from 1st January 2010 to 31st December 2015 after a median follow-up of 4.2 years. Demographic characteristics and clinical variables at baseline were recorded. The primary outcome was new diabetes-related LLA in each year under study. Cox proportional hazard regression models were used to describe the associations of diabetes-related LLA.
resultsThe mean age at enrolment for the cohort was 55.9 ± 14.6 years, with a female preponderance (62.1%). The average incidence rate of diabetes-related LLA was 2.4 (95% CI:1.84-5.61) per 1000 follow-up years: increasing from 0.6% (95% CI:0.21-2.21) per 1000 follow up years in 2010 to 10.9% (95% CI:6.22-12.44) per 1000 follow-up years in 2015. Diabetes-related LLA was associated with increased age at enrollment (for every 10 year increase in age: HR: 1.11, CI: 1.06-1.22, p < 0.001), male gender (HR: 3.50, CI:2.88-5.23, p < 0.01), type 2 diabetes (HR 3.21, CI: 2.58-10.6, p < 0.001), high Body Mass Index (HR: 3.2, CI: 2.51-7.25 p < 0.001), poor glycemic control (for a percent increase in HbA1c, HR:1.11, CI:1.05-1.25, p = 0.03), hypertension (HR:1.14, CI:1.12-3.21 p < 0.001), peripheral sensory neuropathy (HR:6.56 CI:6.21-8.52 p < 0.001) and peripheral vascular disease (HR: 7.73 CI: 4.39-9.53, p < 0.001).
conclusionThe study confirms a high incidence of diabetes related-LLA in Ghana. Interventions aimed at addressing systemic and patient-level barriers to good vascular risk factor control and proper foot care for diabetics should be introduced in LMICs to stem the tide of the increasing incidence of LLA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.